60967-14-8Relevant articles and documents
Organocuprate Conjugate-addition-Enolate-alkylation Reactions: A New Synthesis of 11-Deoxyprostaglandins
Dixon, Andrew J.,Taylor, Richard J. K.,Newton, Roger F.
, p. 1407 - 1410 (1981)
A short synthesis of a key 11-deoxyprostaglandin precursor, 6β--cis-α-2-oxabicyclooctan-3-one (11), is reported.Important reactions in the synthesis include preparation of 2α-allyl-3β-oct-1-enyl>cyclopentanone (4) by an organocuprate conjugate-addition-enolate-alkylation reaction, regiospecific epoxidation-cyclisation of the alcohol (7) to give 6β-oct-1-enil>-3-hydroxymethyl-cis-α-2-oxabicyclooctane (9), and oxidative degradation of (9) with manganese dioxide to give 6β-oct-1-enyl)-cis-α-2-oxabicyclooctan-3-one (10).
Novel compounds of the 11-deoxyprostaglandin E3, R3α, and F3β series
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, (2008/06/13)
This disclosure describes compounds of the 11-deoxyprostaglandin E2, F2α, F2β, E3, F3α, and F3β series having bronchodilator activity.