6097-08-1

Basic information

• Product Name: 6-PHTHALIMIDO-1-HEXYNE
• Synonyms: TIMTEC-BB SBB008977;N-HEX-5-YNYLPHTHALIMIDE;N-(5-HEXYNYL)PHTHALIMIDE;6-PHTHALIMIDO-1-HEXYNE;6-Phthalimido-1-hexyne, N-Hex-5-ynylphthalimide;N-(5-Hexynyl)phthalimide >=95%;2-(hex-5-ynyl)isoindoline-1,3-dione;2-(Hex-5-yn-1-yl)isoindoline-1,3-dione
• CAS NO: 6097-08-1
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.26
• Mol File: 6097-08-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 68-72 °C(lit.)
• Boiling Point: 360.2°C at 760 mmHg
• Flash Point: 157°C
• Appearance: /
• Density: 1.196g/cm³
• Vapor Pressure: 2.25E-05mmHg at 25°C
• Refractive Index: 1.581
• PKA: -2.14±0.20(Predicted)
• CAS DataBase Reference: 6-PHTHALIMIDO-1-HEXYNE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-PHTHALIMIDO-1-HEXYNE(6097-08-1)
• EPA Substance Registry System: 6-PHTHALIMIDO-1-HEXYNE(6097-08-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 6097-08-1(Hazardous Substances Data)

Usage

Description

6-PHTHALIMIDO-1-HEXYNE is an organic compound that serves as a key intermediate in the synthesis of various chemical compounds. It is derived from N-(5-Hexynyl)phthalimide and is characterized by its unique structure, which includes a phthalimide group and a hexyne chain.

Uses

Used in Organic Synthesis:
6-PHTHALIMIDO-1-HEXYNE is used as a reactant in various organic synthesis reactions, including TBAF-catalyzed monoreduction, ruthenium-catalyzed hydrative conjugative addition to alkenes, regioselective nickel-catalyzed carbocyanation reactions, zinc-catalyzed intermolecular hydroaminations, and copper-catalyzed cycloaddition with azides. These reactions enable the formation of a wide range of chemical compounds with diverse applications.
Used in the Synthesis of Amino-Alkyne:
6-PHTHALIMIDO-1-HEXYNE is used as a starting material for the preparation of 6-amino-1-hexyne, which is an important building block in the synthesis of amino-alkyne compounds. These compounds have potential applications in various fields, such as pharmaceuticals, materials science, and chemical research.

InChI:InChI=1/C14H13NO2/c1-2-3-4-7-10-15-13(16)11-8-5-6-9-12(11)14(15)17/h1,5-6,8-9H,3-4,7,10H2

Upstream product

• 136918-14-4 phthalimide 
• 10297-06-0 1-chloro-5-hexyne 
• 66977-99-9 6-bromo-1-hexyne 
• 1074-82-4 potassium phtalimide 
• 928-90-5 5-hexyl-1-ol 

Downstream Products

• 102169-54-0 hex-5-yn-1-amine monohydrochloride 
• 1354023-28-1 2-(6-(2-ethynylphenyl)hex-5-yn-1-yl)isoindoline-1,3-dione 
• 92040-47-6 N-(5-oxohexyl)benzamide 
• 71510-41-3 2-(5-oxohexyl)-1H-isoindole-1,3(2H)-dione 
• 129508-51-6 N-(hex-5-ynyl)benzamide 
• 15252-45-6 1-amino-5-hexyne 
• 350508-86-0 2-(6-phenylselanyl-hex-5-ynyl)-isoindole-1,3-dione 

Relevant articles and documents

Development of Robust 17(R),18(S)-Epoxyeicosatetraenoic Acid (17,18-EEQ) Analogues as Potential Clinical Antiarrhythmic Agents

17(R),18(S)-Epoxyeicosatetraenoic acid (EEQ) is a cytochrome P450 metabolite of eicosapentaenoic acid (EPA) and a powerful negative chronotrope with low nanomolar activity in a neonatal rat cardiomyocyte (NRCM) arrhythmia model. Prior studies identified oxamide 2b as a soluble epoxide hydrolase (sEH) stable replacement but unsuitable for in vivo applications due to limited oral bioavailability and metabolic stability. These ADME limitations have been addressed in an improved generation of negative chronotropes, e.g., 4 and 16, which were evaluated as potential clinical candidates.

One-Pot Double-Annulation Strategy for the Synthesis of Unusual Fused Bis-Heterocycles

A novel metal-free double-annulation cascade for the construction of unusual fused heterocyclic systems is described. This simple protocol enables the sequential assembly of two rings in one pot from two simple precursors. Acidic conditions promote the condensation and the intramolecular alkynyl Prins reaction of an enyne or arenyne alcohol with a cyclic hemiaminal to form a five-, six-, or seven-membered oxacycle followed by a seven-or eight-membered azacycle. In this transformation, chemical complexity is rapidly generated with the formation of three new bonds (one C-O, one C-C, and one C-N) in one synthetic operation. The strategy is modular and relatively general, providing access to a series of unique fused bicyclic scaffolds.

Halogen-Bond-Promoted Photoactivation of Perfluoroalkyl Iodides: A Photochemical Protocol for Perfluoroalkylation Reactions

A new protocol for photochemical perfluoroalkylation reactions using perfluoroalkyl iodide, amine additive, and THF solvent is reported. This protocol does not require a photoredox catalyst and proceeds at ambient temperature with irradiation from a compact fluorescent lamp, low-intensity UV lamp, or sunlight. This protocol can be applied to the synthesis of perfluoroalkyl-substituted phenanthridines as well as effect the iodo-perfluoroalkylation of alkenes/alkynes and the C-H perfluoroalkylation of electron-rich arenes and heteroarenes. This C-H perfluoroalkylation reaction offers a unique method for site-selective labeling of oligopeptides at the tryptophan residue.