609806-40-8

Basic information

• Product Name: 4-Hydroxymethyl Loratadine
• Synonyms: Loratadine 4-Hydroxymethyl Impurity (USP);4-[8-Chloro-5,6-dihydro-4-(hydroxymethyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylic Acid Ethyl Este;4-[8-Chloro-5,6-dihydro-4-(hydroxymethyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylic Acid Ethyl Ester;Ethyl 4-[8-chloro-5,6-dihydro-4-(hydroxy methyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidine carboxylate;Loratadine Impurity 4
• CAS NO: 609806-40-8
• Molecular Formula: C23H25ClN2O3
• Molecular Weight: 412.914
• Product Categories: Metabolites & Impurities;Pharmaceuticals;Intermediates & Fine Chemicals
• Mol File: 609806-40-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 73-75°C
• Boiling Point: 594.2°C at 760 mmHg
• Flash Point: 313.2°C
• Appearance: /
• Density: 1.301g/cm³
• Vapor Pressure: 5.76E-15mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: 13.56±0.10(Predicted)
• CAS DataBase Reference: 4-Hydroxymethyl Loratadine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxymethyl Loratadine(609806-40-8)
• EPA Substance Registry System: 4-Hydroxymethyl Loratadine(609806-40-8)

Safety Data

• Hazardous Substances Data: 609806-40-8(Hazardous Substances Data)

Usage

Description

4-Hydroxymethyl Loratadine is a light-yellow solid that is commonly found as an impurity in Loratadine syrup formulations. It is a nonsedating-type histamine H1-receptor, which means it can help alleviate allergy symptoms without causing drowsiness.

Uses

Used in Pharmaceutical Industry:
4-Hydroxymethyl Loratadine is used as an impurity in Loratadine syrup formulations for its nonsedating properties. It helps to provide relief from allergy symptoms such as sneezing, itching, and watery eyes without causing drowsiness, making it a preferred choice for patients who need to remain alert during the day.
Used in Allergy Treatment:
4-Hydroxymethyl Loratadine is used as a nonsedating histamine H1-receptor antagonist for the treatment of various allergic conditions. Its ability to block histamine receptors helps to reduce the symptoms of allergies, such as itching, redness, and swelling, without causing drowsiness or sedation.
Used in Research and Development:
As a light-yellow solid, 4-Hydroxymethyl Loratadine can be used in research and development for the study of histamine H1-receptors and the development of new antihistamine drugs. Its properties can be investigated to understand its interaction with histamine receptors and its potential use in the treatment of allergies and other related conditions.

InChI:InChI=1/C23H25ClN2O3/c1-2-29-23(28)26-11-8-15(9-12-26)21-19-6-4-18(24)13-16(19)3-5-20-17(14-27)7-10-25-22(20)21/h4,6-7,10,13,27H,2-3,5,8-9,11-12,14H2,1H3