61-12-1

Basic information

• Product Name: Dibucaine hydrochloride
• Synonyms: 2-butoxy-n-(2-(diethylamino)ethyl)-4-quinolinecarboxamidmonohydrochlorid;2-butoxy-n-(2-(diethylamino)ethyl)-cinchoninamidmonohydrochloride;2-butoxy-n-(2-diethylaminoethyl)cinchoninicacidamidehydrochloride;2-n-butoxy-n-(2-diethylaminoethyl)cinchoninamidehydrochloride;4-Quinolinecarboxamide,2-butoxy-N-[2-(diethylamino)ethyl]-,monohydrochloride;benzolin(localanesthetic);butoxycinchoninicaciddiethylethylenediamidehydrochloride;c3225
• CAS NO: 61-12-1
• Molecular Formula: C20H30ClN3O2
• Molecular Weight: 379.92
• EINECS: 200-498-1
• Product Categories: Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;NUPERCAINAL;Other APIs
• Mol File: 61-12-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 99-101 °C(lit.)
• Boiling Point: 496.3 °C at 760 mmHg
• Flash Point: 254 °C
• Appearance: white powder
• Density: 1.1338 (rough estimate)
• Vapor Pressure: 3.37E-12mmHg at 25°C
• Refractive Index: 1.5400 (estimate)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Water Solubility: Freely soluble in water, alcohol, acetone, or chloroform
• Stability: Stable. Incompatible with strong oxidizing agents. Protect from moisture.
• Merck: 13,3057
• CAS DataBase Reference: Dibucaine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Dibucaine hydrochloride(61-12-1)
• EPA Substance Registry System: Dibucaine hydrochloride(61-12-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• RTECS: GD3325000
• Hazardous Substances Data: 61-12-1(Hazardous Substances Data)

Usage

Chemical Properties

white powder

Uses

Different sources of media describe the Uses of 61-12-1 differently. You can refer to the following data:
1. Cinchocaine is used as an anaesthetic agent for spinal anaesthesia; a component in rectal medications used in inflammation of the anus and for the symptomatic treatment of hemorrhoids and fissures in the anus; local anesthetic agent.
2. Dibucaine HCl is an amide-like quinoline derivative and is one of the most potent and longest acting of the commonly used local anesthetics.

Definition

ChEBI: The monohydrochloride salt of cinchocaine. It is used in creams, ointments and suppositories for temporary relief of pain and itching associated with skin and anorectal conditions.

Brand name

Nupercaine (Novartis).

Contact allergens

Dibucaine hydrochloride is an amide group local anesthetic that can induce allergic contact dermatitis.

Safety Profile

Poison by ingestion,subcutaneous, intravenous, intraspinal, parenteral, andintraperitoneal routes. Mutation data reported. A severeeye irritant. A local anesthetic. When heated todecomposition it emits very toxic fumes of HCl and NOx

InChI:InChI=1/C20H29N3O2.2ClH/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3;;/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24);2*1H