61010-34-2

Basic information

• Product Name: 4-Methoxy-3-nitrobenzyl bromide
• Synonyms: 4-METHOXY-3-NITROBENZYL BROMIDE;3-nitro-4-methoxybenyl bromide;3-NITRO-4-METHOXYBENZYL BROMIDE;Benzene, 4-(broMoMethyl)-1-Methoxy-2-nitro-
• CAS NO: 61010-34-2
• Molecular Formula: C₈H₈BrNO₃
• Molecular Weight: 246.06
• Mol File: 61010-34-2.mol
• Article Data: 21

Chemical Properties

• Melting Point: 108 °C
• Boiling Point: 353.7 ºC at 760 mmHg
• Flash Point: 167.7 ºC
• Appearance: /
• Density: 1.589 g/cm₃
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Methoxy-3-nitrobenzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-3-nitrobenzyl bromide(61010-34-2)
• EPA Substance Registry System: 4-Methoxy-3-nitrobenzyl bromide(61010-34-2)

Safety Data

• Hazardous Substances Data: 61010-34-2(Hazardous Substances Data)

Usage

Description

4-Methoxy-3-nitrobenzyl bromide is an organic compound that serves as a valuable intermediate in the synthesis of various organic molecules. It is characterized by the presence of a nitro group, a methoxy group, and a bromine atom attached to a benzene ring. This versatile structure allows for further functionalization and incorporation into a wide range of chemical products.

Uses

Used in Pharmaceutical Industry:
4-Methoxy-3-nitrobenzyl bromide is used as a starting material for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Industry:
4-Methoxy-3-nitrobenzyl bromide is used as a building block for the creation of various organic compounds in the chemical industry. Its reactivity and functional groups make it a suitable candidate for the production of dyes, pigments, and other specialty chemicals.
Used in Research and Development:
4-Methoxy-3-nitrobenzyl bromide is utilized as a key intermediate in the research and development of new chemical entities. Its unique structure and reactivity make it an attractive candidate for exploring novel chemical reactions and synthesizing new molecules with potential applications in various fields.

InChI:InChI=1/C8H8BrNO3/c1-13-8-3-2-6(5-9)4-7(8)10(11)12/h2-4H,5H2,1H3

Upstream product

• 876494-02-9 1-methoxy-4-methoxymethyl-2-nitro-benzene 
• 41833-13-0 4-hydroxymethyl-2-nitrophenol 
• 74-88-4 methyl iodide 
• 123-11-5 4-methoxy-benzaldehyde 
• 3011-34-5 4-hydroxy-3-nitrobenzaldehyde 
• 119-10-8 4-methoxy-3-nitrotoluene 
• 119-33-5 4-methyl-2-nitrophenol 
• 31680-08-7 4-methoxy-3-nitrobenzaldehyde 
• 41870-24-0 (4-methoxy-3-nitrophenyl)methanol 

Downstream Products

• 22216-44-0 2-(4-methoxy-3-nitrobenzylthio)acetic acid 
• 1092367-05-9 diethyl (4-methoxy-3-nitrobenzyl)phosphonate 
• 592542-59-1 (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetic acid 
• 852283-21-7 (E)-2-methoxy-5-((2,4,6-trimethoxystyrylsulfinyl)methyl)aniline 
• 592542-51-3 4-methoxy-3-nitrophenylmethanesulfonyl acetic acid 
• 1310065-00-9 2-(4-methoxy-3-nitrobenzylsulfonyl)acetyl chloride 
• 1310064-84-6 C₁₉H₂₁NO₈S 
• 852283-23-9 (E)-1,3,5-trimethoxy-2-(2-(4-methoxy-3-nitrobenzylsulfinyl)vinyl)benzene 
• 1310064-99-3 C₂₃H₂₉NO₈S 
• 1310064-86-8 C₁₈H₁₉NO₇S 
• 592542-50-2 (E)-2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)aniline 
• 1310064-87-9 C₁₉H₂₃NO₆S 
• 1310064-88-0 (E)-2',5'-dimethoxystyryl-4-methoxy-3-aminobenzylsulfone 
• 1310064-89-1 C₁₈H₂₁NO₅S 

Relevant articles and documents

Synthesis and antitumor effects of novel benzyl naphthyl sulfoxide/sulfone derivatives derived from Rigosertib

In this work, a series of novel benzyl naphthyl sulfoxides/sulfones derived from Rigosertib were designed and synthesized as potential antitumor agents. The in vitro cytotoxicity against four human cancer cell lines (HeLa, MCF-7, HepG2 and SCC-15) and two normal human cell lines (HUVEC and 293T) indicated that some of the sulfones and sulfoxides possessed potent antineoplastic activity that reached nanomolar levels and relatively low toxicity to normal cells. Among them, (2-methoxy-5-((naphthalen-2-ylsulfonyl)methyl)phenyl)glycine (15b) was found to be a promising antitumor drug candidate that could significantly inhibit tumor cell migration and induce tumor cell apoptosis via the p53-Bcl-2-Bax signaling pathway at nanomolar concentrations.

INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE

The present invention provides compounds of formula (I) wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.

Synthesis and Biological Evaluation of 1,2,3-triazole tethered Pyrazoline and Chalcone Derivatives

A series of pyrazoline derivatives and corresponding chalcone intermediates with substituents same as combretastatin-A4(CA-4) conjugated with triazole nucleus has been synthesized and evaluated for their anticancer potential. Sulphorhodamine B(SRB) assay indicated compound 12c to be the most active compound from the series with GI50 value of 6.7 μm against the human liver carcinoma cell line HepG2. Interestingly, the intermediate 11c exhibited more promising cytotoxicity demonstrating GI50 value of 1.3 μm against the prostate cancer cell line DU145. Compounds 11c and 12c caused accumulation of cells in G2/M phase and inhibited tubulin polymerization. Furthermore, these compounds reduce the mitochondrial membrane potential and activate caspases 3 and 9, thereby indicating their ability to trigger apoptosis.