61012-46-2 Usage
Description
METHYL CIS CIS-11 14-EICOSADIENOATE, also known as 11(Z),14(Z)-Eicosadienoic acid methyl ester, is a more lipid-soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid, a naturally occurring polyunsaturated fatty acid (PUFA). It has been found to have various biological activities, including the competitive inhibition of inosine 5'-monophosphate dehydrogenase and the inhibition of the binding of leukotriene B4 (LTB4) to its receptor on neutrophils. Additionally, serum levels of eicosadienoic acids have been observed to negatively correlate with the degree of sleep disturbance.
Uses
Used in Pharmaceutical Industry:
METHYL CIS CIS-11 14-EICOSADIENOATE is used as a therapeutic agent for its anti-inflammatory properties. It competitively inhibits inosine 5'-monophosphate dehydrogenase (Ki = 3.1 μM), which plays a role in the synthesis of leukotrienes, inflammatory mediators involved in various diseases, including asthma and inflammatory bowel disease.
Used in Immunology Research:
METHYL CIS CIS-11 14-EICOSADIENOATE is used as a research tool for studying the binding of leukotriene B4 (LTB4) to its receptor on neutrophils (Ki = 3.0 μM). This helps in understanding the role of LTB4 in immune response and inflammation, as well as in the development of new drugs targeting this pathway.
Used in Sleep Research:
METHYL CIS CIS-11 14-EICOSADIENOATE is used as a biomarker in sleep research due to its negative correlation with the degree of sleep disturbance. This can help in understanding the role of eicosadienoic acids in sleep regulation and the development of potential treatments for sleep disorders.
Used in Cardiovascular Research:
METHYL CIS CIS-11 14-EICOSADIENOATE is used as a precursor in the conversion of eicosadienoic acids to eicosatrienoic acids by desaturases, in vivo. Eicosatrienoic acids are potent vasodilators, which can help in the study and development of treatments for cardiovascular diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 61012-46-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,0,1 and 2 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 61012-46:
(7*6)+(6*1)+(5*0)+(4*1)+(3*2)+(2*4)+(1*6)=72
72 % 10 = 2
So 61012-46-2 is a valid CAS Registry Number.
InChI:InChI=1/C21H38O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21(22)23-2/h7-8,10-11H,3-6,9,12-20H2,1-2H3/b8-7-,11-10-
61012-46-2Relevant articles and documents
Valorization of Unconventional Lipids from Microalgae or Tall Oil via a Selective Dual Catalysis One-Pot Approach
Hess, Sandra K.,Schunck, Natalie S.,Goldbach, Verena,Ewe, Daniela,Kroth, Peter G.,Mecking, Stefan
supporting information, p. 13487 - 13491 (2017/10/05)
A dual catalysis approach enables selective functionalization of unconventional feedstocks composed of complex fatty acid mixtures with highly unsaturated portions like eicosapentaenoate (20:5) along with monounsaturated compounds. The degree of unsaturation is unified by selective heterogeneous hydrogenation on Pd/γ-Al2O3, complemented by effective activation to a homogeneous carbonylation catalyst [(dtbpx)PdH(L)]+ by addition of diprotonated diphosphine (dtbpxH2)(OTf)2. By this one-pot approach, neat 20:5 as a model substrate is hydrogenated to up to 80% to the monounsaturated analogue (20:1), this is functionalized to the desired C21 α,ω-diester building block with a linear selectivity of over 90%. This catalytic approach is demonstrated to be suitable for crude microalgae oil from Phaeodactylum tricornutum genetically engineered for this purpose, as well as tall oil, an abundant waste material. Both substrates were fully converted with an overall selectivity to the linear α,ω-diester of up to 75%.