61057-98-5

Basic information

• Product Name: (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid
• Synonyms: (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid
• CAS NO: 61057-98-5
• Molecular Weight: 331.375
• Mol File: 61057-98-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid(61057-98-5)
• EPA Substance Registry System: (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid(61057-98-5)

Safety Data

• Hazardous Substances Data: 61057-98-5(Hazardous Substances Data)

Upstream product

• 41324-66-7 H-Pro-OBzl 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 608533-81-9 diphenylphosphine proline methyl ester 
• 1079-66-9 chloro-diphenylphosphine 
• 282088-13-5 (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 444901-94-4 (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid benzyl ester 

Downstream Products

• 444901-95-5 (R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester 
• 444901-96-6 (R)-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-phenyl-acetic acid methyl ester 
• 444901-98-8 (R)-2-[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidin-2-yl]-4-phenyl-4,5-dihydro-oxazole 
• 608533-93-3 (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid ((R)-1-hydroxymethyl-2-methyl-propyl)-amide 
• 666727-83-9 (R)-4-tert-Butyl-2-[(S)-1-(diphenyl-phosphinothioyl)-pyrrolidin-2-yl]-4,5-dihydro-oxazole 
• 444901-99-9 (S)-2-[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidin-2-yl]-4-isopropyl-4,5-dihydro-oxazole 
• 444901-97-7 (R)-2-[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidin-2-yl]-4-isopropyl-4,5-dihydro-oxazole 
• 666723-36-0 (R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3,3-dimethyl-butyric acid 

Relevant articles and documents

Two-fold amino acid-based chiral aminophosphine-oxazolines and use in asymmetric allylic alkylation

Chiral aminophosphine-oxazoline ligands derived from two different amino acids (tetrahydroisoquinoline carboxylic acid and proline) have been synthesized and examined as chiral auxiliaries in asymmetric allylic alkylation of three substrates. Stereoisomers 1a and 2a are providing the highest enantioselectivities (up to 94% ee) in the allylation of diphenylpropenyl acetate.

Facile synthesis of proline based phosphine-oxazoline ligands by formation of a P-N bond

A series of new P-N ligands in which the phosphorus moiety is introduced by formation of a phosphorus-heteroatom bond are synthesized. These ligands are based on proline with chiral centers from both proline and an oxazoline. The two chiral centers are re