61151-97-1

Basic information

• Product Name: 4-Oxazolecarboxylic acid, 2-(4-chlorophenyl)-5-methyl-, ethyl ester
• CAS NO: 61151-97-1
• Molecular Formula: C13H12ClNO3
• Molecular Weight: 265.696
• Mol File: 61151-97-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-Oxazolecarboxylic acid, 2-(4-chlorophenyl)-5-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxazolecarboxylic acid, 2-(4-chlorophenyl)-5-methyl-, ethyl ester(61151-97-1)
• EPA Substance Registry System: 4-Oxazolecarboxylic acid, 2-(4-chlorophenyl)-5-methyl-, ethyl ester(61151-97-1)

Safety Data

• Hazardous Substances Data: 61151-97-1(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 104-86-9 4-chlorobenzylamine 
• 1144520-57-9 ethyl 2-chloro-5-methyloxazole-4-carboxylate 
• 1679-18-1 4-Chlorophenylboronic acid 
• 5408-04-8 ethyl 2-hydroxyimino-3-oxobutanoate 
• 122-01-0 4-chloro-benzoyl chloride 
• 61151-91-5 2-(4-chloro-benzoylamino)-3-oxo-butyric acid ethyl ester 

Downstream Products

• 1144520-81-9 C₁₂H₁₁ClN₄O₂ 
• 51655-78-8 2-(4-chloro-phenyl)-5-methyl-oxazole-4-carbonyl chloride 
• 51655-77-7 2-(4-chloro-phenyl)-5-methyl-oxazole-4-carboxylic acid amide 
• 2940-23-0 2-(4-chloro-phenyl)-5-methyl-oxazole-4-carboxylic acid 
• 80022-69-1 2-(4-Chloro-phenyl)-10H-1-oxa-9-thia-3-aza-benzo[f]azulen-4-one 
• 80022-66-8 2-(4-Chloro-phenyl)-10H-1,9-dioxa-3-aza-benzo[f]azulen-4-one 

Relevant articles and documents

miRNA biosynthesis inhibitor

The invention provides a compound shown as a formula I, or a conformational isomer thereof, or an optical isomer thereof, or a pharmaceutically acceptable salt thereof. The compound can be tightly combined with related binding proteins in an miRNA biosynthesis process and can effectively inhibit the synthesis of miRNA-21. The prepared active compound provided by the invention can be used as an miRNA-21 inhibitor, and further as a potential drug for treating malignant tumors. The formula I is shown in the description.

Convenient route to trisubstituted oxazoles via a copper-catalysed tandem oxidative cyclisation by oxygen oxidation

A novel copper-catalysed oxidative cyclisation has been developed for the synthesis of trisubstituted oxazoles, which is thought to proceed through cascade formation of C-N and C-O bonds by oxygen oxidation. The desired products can be obtained from readily available starting materials while avoiding hazardous materials. Therefore, a green synthetic method for the preparation of oxazoles has been found.

Metal-free, organocatalytic cascade formation of C-N and C-O bonds through dual sp3 C-H activation: Oxidative synthesis of oxazole derivatives

An organocatalytic cascade reaction that involves the formation of C-N, C-O and CN bonds in one process via dual sp3 C-H activation has been developed. This protocol affords a facile metal-free methodology for the synthesis of oxazole derivatives in air under mild conditions.