6116-75-2

Basic information

• Product Name: 2,3-dimethyl-1,5,6,7-tetrahydro-4H-indol-4-one
• Synonyms: 2,3-dimethyl-6,7-dihydro-1H-indol-4(5H)-one
• CAS NO: 6116-75-2
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.2163
• Mol File: 6116-75-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 351.6°C at 760 mmHg
• Flash Point: 174.3°C
• Density: 1.136g/cm³
• Vapor Pressure: 4.08E-05mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 2,3-dimethyl-1,5,6,7-tetrahydro-4H-indol-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dimethyl-1,5,6,7-tetrahydro-4H-indol-4-one(6116-75-2)
• EPA Substance Registry System: 2,3-dimethyl-1,5,6,7-tetrahydro-4H-indol-4-one(6116-75-2)

Safety Data

• Hazardous Substances Data: 6116-75-2(Hazardous Substances Data)

Usage

General Description

2,3-dimethyl-1,5,6,7-tetrahydro-4H-indol-4-one is a chemical compound with the molecular formula C11H15NO. It is a cyclic organic compound that contains a five-membered ring with a nitrogen atom. This chemical is also known as Ropinirole, and it is commonly used as a medication to treat Parkinson's disease and restless legs syndrome. Ropinirole works by acting as a dopamine agonist, which means it stimulates dopamine receptors in the brain to help improve motor function and reduce the symptoms of Parkinson's disease. Additionally, it can also help alleviate the uncomfortable sensations in the legs experienced by individuals with restless legs syndrome. Overall, 2,3-dimethyl-1,5,6,7-tetrahydro-4H-indol-4-one is an important compound with therapeutic applications in the treatment of neurological disorders.

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 10412-98-3 5-oxohexanenitrile 
• 1609011-32-6 3-aminocyclohex-2-ene-1-one potassium salt 
• 814-75-5 3-bromo-butanone 
• 57-71-6 2,3-Butanedione monoxime 
• 135636-66-7 butane-2,3-dione mono-oxime 

Downstream Products

• 1432509-88-0 methyl 4-((2,3-dimethyl-4-oxo-4,5,6,7-tetrahydroindol-1-yl)methyl)benzoate 
• 1432508-68-3 4-((2,3-dimethyl-4-oxo-4,5,6,7-tetrahydroindol-1-yl)methyl)-N-hydroxybenzamide 
• 7273-21-4 1,2,3-Trimethyl-4-oxo-4,5,6,7-tetrahydroindole 

Relevant articles and documents

Urea decomposition: Efficient synthesis of pyrroles using the deep eutectic solvent choline chloride/urea

A simple and efficient method is reported for the synthesis of pyrroles via condensation of a series of tricarbonyl compounds with ammonia, which was generated in situ from decomposition of the deep eutectic solvent choline chloride/urea.

HYDROXAMATE DERIVATIVES FOR HDAC INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THEREOF

The present invention relates to a novel hydroxamate derivatives, more specifically, to novel hydroxamate derivatives having inhibitory activity against Histone Deacetylase (HDAC), isomers thereof, pharmaceutically acceptable salts thereof, hydrates or solvates thereof, use for preparing pharmaceutical compositions, pharmaceutical compositions comprising the same, treatment method using said composition, and a preparing method of novel hydroxamate derivatives. The novel selective hydroxamate derivatives having inhibitory activity against Histone Deacetylase (HDAC) compositions can be used for treatment of inflammatory disease, rheumatoid arthritis, or degenerative disease.

Discovery and synthesis of tetrahydroindolone derived semicarbazones as selective Kv1.5 blockers

A novel class of tetrahydroindolone-derived semicarbazones has been discovered as potent Kv1.5 blockers. In in vitro studies, several compounds exhibited very good potency for blockade of Kv1.5. Compound 8i showed good selectivity for blockade of Kv1.5 vs hERG and L-type calcium channels. In an anesthetized pig model, compounds 8i and 10c increased atrial ERP about 28%, 18%, respectively, in the right atrium without affecting ventricular ERP.