61184-95-0

Basic information

• Product Name: (S)-1-phenylethyl (R)-α-methoxy-α-trifluoromethylphenylacetate
• Synonyms: (S)-1-phenylethyl (R)-α-methoxy-α-trifluoromethylphenylacetate
• CAS NO: 61184-95-0
• Molecular Weight: 338.326
• Mol File: 61184-95-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (S)-1-phenylethyl (R)-α-methoxy-α-trifluoromethylphenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-phenylethyl (R)-α-methoxy-α-trifluoromethylphenylacetate(61184-95-0)
• EPA Substance Registry System: (S)-1-phenylethyl (R)-α-methoxy-α-trifluoromethylphenylacetate(61184-95-0)

Safety Data

• Hazardous Substances Data: 61184-95-0(Hazardous Substances Data)

Upstream product

• 98-85-1 1-Phenylethanol 
• 20445-31-2 R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid 
• 20445-33-4 (R)-methoxytrifluoromethylphenylacetyl chloride 
• 1445-91-6 (S)-1-phenylethanol 
• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 
• 1122-58-3 dmap 

Relevant articles and documents

Laboratory scale-up synthesis of chiral carbinols using Rhizopus arrhizus

Rhizopus arrhizus mediated bioreduction was optimized using acetophenone as a model substrate. Various parameters such as bio-processing conditions, reaction time, substrate concentration, temperature, and solvent carrier were studied. This optimized protocol was further exploited for scaled up bioreductions of various prochiral ketones. This study demonstrates the versatility of the fungus Rhizopus arrhizus as a biocatalyst to obtain chiral carbinols in good to excellent yields and selectivities.

A simple method for the microscale preparation of Mosher's acid chloride

Mosher's acid is treated with oxalyl chloride in the presence of DMF in hexane. Filtration and concentration provide the acid chloride which is suitable for use without further purification. The procedure is amenable to microscale.

Kinetic resolution of racemic alcohols with chiral carboxylic acids and dicyclohexylcarbodiimide

The DCC-esterification method has been used to kinetically resolve racemic mixtures of alcohols. With simple chiral carboxylic acids, such as O-aryl lactic acids, in the presence of various basic catalysts, mixtures of the enantiomerically enriched alcohols (e.e. 50%) and the corresponding esters (d.e. 70%) have been obtained.