6119-70-6 Usage
Description
Quinine sulfate dihydrate is a white or almost white, crystalline powder or fine, colorless needles that is odorless and has a persistent, very bitter taste. It darkens on exposure to light, and its saturated solution is neutral or alkaline to litmus. It is a derivative of quinine, a natural alkaloid found in the bark of the cinchona tree, and is commonly used for its medicinal properties.
Uses
Used in Pharmaceutical Industry:
Quinine sulfate dihydrate is used as an antimalarial agent for treating malaria, a disease caused by parasites that infect red blood cells. It is effective against the Plasmodium species responsible for malaria, helping to reduce the severity and duration of the illness.
Quinine sulfate dihydrate is also used as an antipyreticum, which means it is employed to reduce fever and alleviate symptoms associated with high body temperature.
Additionally, it is used in the formulation of tonics and other liquid medications, where its antimalarial and antipyretic properties can be beneficial.
Used in Potassium Channel Blockers:
In the field of cardiovascular research and drug development, quinine hemisulfate monohydrate, a related compound, plays a major role as a potassium channel blocker. It is used as an antimalarial, anticholinergic, antihypertensive, and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channels, which can have various therapeutic applications.
Furthermore, quinine hemisulfate monohydrate is used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to investigate the toxicity of heme (FP)-complexes, contributing to a better understanding of malaria and its treatment.
Synthesis
Manufacture of quinine by extraction from cinchona bark and subsequent purification and synthesis to quinine sulfate
Check Digit Verification of cas no
The CAS Registry Mumber 6119-70-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,1 and 9 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6119-70:
(6*6)+(5*1)+(4*1)+(3*9)+(2*7)+(1*0)=86
86 % 10 = 6
So 6119-70-6 is a valid CAS Registry Number.
InChI:InChI=1/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m00.../s1
