612-12-4 Usage
Description
1,2-Bis(chloromethyl)benzene, also known as α,α'-dichloro-o-xylene, is an organic compound characterized by the presence of two chloromethyl groups attached to a benzene ring. This chemical structure endows it with unique properties that make it suitable for various applications, particularly in the field of organic synthesis.
Uses
Used in Pharmaceutical Industry:
1,2-Bis(chloromethyl)benzene is used as a synthetic intermediate for the solid-phase synthesis of large combinatorial variations of fundamental peptide units. Its ability to facilitate the formation of peptide bonds in a controlled manner is crucial for the development of new drugs and therapeutic agents.
Used in Chemical Research:
In the field of chemical research, 1,2-bis(chloromethyl)benzene serves as a versatile building block for the synthesis of various organic compounds. Its reactivity and functional groups make it an ideal candidate for the creation of complex molecules with potential applications in different industries.
Used in Material Science:
1,2-Bis(chloromethyl)benzene is also utilized in material science for the development of novel polymers and resins. Its unique structure allows for the creation of materials with specific properties, such as enhanced stability, improved mechanical strength, or tailored chemical reactivity.
Safety Profile
Poison by intravenous
route. Mutation data reported. See also
CHLORINATED HYDROCARBONS,
AROMATIC. When heated to
decomposition it emits toxic Cl-.
Check Digit Verification of cas no
The CAS Registry Mumber 612-12-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 2 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 612-12:
(5*6)+(4*1)+(3*2)+(2*1)+(1*2)=44
44 % 10 = 4
So 612-12-4 is a valid CAS Registry Number.
612-12-4Relevant articles and documents
Previdi,Krause
, p. 647 (1971)
Improved Halogenation of Methyl Aromatics and Methyl Heteroaromatics: Unexpected Reactivity of Tetrahalogeno-diphenylglycolurils
Moretti, Florian,Poisson, Guillaume,Marsura, Alain
, p. 173 - 183 (2016/05/19)
1,3,4,6-Tetrachloro (TCDGU) and 1,3,4,6-tetrabromo-3α,6α-diphenylglycolurils smooth halogen oxidizers have been exploited in a new direction as reagents for free radical substitution toward some N-halosuccinimide nonreactive bis-heterocycles. An unexpected selectivity and reactivity were observed with methyl benzenes, methyl heterocycles, and methyl-bis-heterocycles of interest. A chemometric study has been performed to optimize five independent factors of the chlorination reaction with TCDGU. The predictive model was established either for the halogenation conversion and the ratio of monochlorination.
Interpretation of retention indices in gas chromatography for establishing structures of isomeric products of alkylarenes radical chlorination
Zenkevich
, p. 270 - 280 (2007/10/03)
By an example of previously uncharacterized products obtained by alkylarenes radical chlorination was demonstrated that combination of various interpretation methods applied to the retention indices (RI) in the gas chromatography on the standard nonpolar phases (comparison of RI of products and initial compounds, characteristics of succession of the chromatographic elution of the structural isomers with the use of estimation of molecular dynamic parameters, application of the additive schemes to RI calculation, and using of structural analogy CH3?Cl for testing the results obtained) permitted unambiguous identification of the structure even without data of mass spectrometry.