612082-36-7

Basic information

• Product Name: Pyrrolo[1,2-b]pyridazine-6-carboxylic acid, 3-cyano-5-(hydroxymethyl)-4-[(4-phenoxyphenyl)amino]-, ethyl ester
• CAS NO: 612082-36-7
• Molecular Formula: C24H20N4O4
• Molecular Weight: 428.447
• Mol File: 612082-36-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pyrrolo[1,2-b]pyridazine-6-carboxylic acid, 3-cyano-5-(hydroxymethyl)-4-[(4-phenoxyphenyl)amino]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[1,2-b]pyridazine-6-carboxylic acid, 3-cyano-5-(hydroxymethyl)-4-[(4-phenoxyphenyl)amino]-, ethyl ester(612082-36-7)
• EPA Substance Registry System: Pyrrolo[1,2-b]pyridazine-6-carboxylic acid, 3-cyano-5-(hydroxymethyl)-4-[(4-phenoxyphenyl)amino]-, ethyl ester(612082-36-7)

Safety Data

• Hazardous Substances Data: 612082-36-7(Hazardous Substances Data)

Upstream product

• 5448-16-8 3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 612086-02-9 5-Bromomethyl-4-chloro-3-cyano-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester 
• 612085-98-0 3-Cyano-1,4-dihydro-5-methyl-4-oxopyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester 
• 612085-99-1 4-Chloro-3-cyano-5-methylpyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester 
• 612086-03-0 4-Chloro-3-cyano-5-hydroxymethyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester 
• 139-59-3 4-phenoxyanilin 
• 427878-69-1 1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 

Downstream Products

• 612082-38-9 3-Cyano-5-formyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester 
• 612083-65-5 5-Cyano-7-oxo-6-(4-phenoxy-phenyl)-6,7-dihydro-9H-8-oxa-2a,3,6-triaza-benzo[cd]azulene-1-carboxylic acid ethyl ester 

Relevant articles and documents

Pyrrolopyridazine MEK inhibitors

The synthesis and SAR of a series of pyrrolopyridazine MEK inhibitors are reported. Optimal activity was achieved by incorporation of a 4-phenoxyaniline substituent at C4 and an acylated amine at C6.