61222-95-5

Basic information

• Product Name: Benzenepropanenitrile, a-[(4-nitrophenyl)methylene]-b-oxo-
• CAS NO: 61222-95-5
• Molecular Formula: C16H10N2O3
• Molecular Weight: 278.267
• Mol File: 61222-95-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenepropanenitrile, a-[(4-nitrophenyl)methylene]-b-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanenitrile, a-[(4-nitrophenyl)methylene]-b-oxo-(61222-95-5)
• EPA Substance Registry System: Benzenepropanenitrile, a-[(4-nitrophenyl)methylene]-b-oxo-(61222-95-5)

Safety Data

• Hazardous Substances Data: 61222-95-5(Hazardous Substances Data)

Upstream product

• 614-16-4 Benzoylacetonitrile 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 86625-33-4 1,2-Dihydro-4-(4-nitrophenyl)-6-phenyl-2-thioxo-3,5-pyridinedicarbonitrile 
• 86625-38-9 4,4'-Bis(4-nitrophenyl)-6,6'-diphenyl-2,2'-dithiobis(3,5-pyridinedicarbonitrile) 
• 76593-40-3 4-Cyano-3-hydroxy-5-(4-nitro-phenyl)-3-phenyl-tetrahydro-thiophene-2-carboxylic acid methyl ester 
• 1445582-70-6 tert-butyl 2-((3S,4R,5S)-4-benzoyl-4-cyano-5-(4-nitrophenyl)tetrahydrothiophen-3-yl)acetate 
• 1378998-47-0 C₂₂H₂₀N₂O₄ 
• 100784-47-2 3-carbamoyl-5-cyano-4-(p-nitrophenyl)-6-phenyl-3,4-dihydropyridin-2(1H)-one 
• 100784-52-9 3-carbamoyl-5-cyano-4-(p-nitrophenyl)-6-phenylpyridin-2(1H)-one 
• 100784-56-3 5-cyano-4-(p-nitrophenyl)-6-phenylpyridin-2(1H)-one 
• 86634-62-0 2-Methylthio-4-(4-nitrophenyl)-6-phenyl-3,5-pyridinedicarbonitrile 

Relevant articles and documents

One-pot highly diastereoselective annulation to N-unprotected tetrasubstituted 2-pyrrolines

A one-pot DABCO-catalysed Michael addition of glycine imine-derived esters to trans-2-aroyl-3-arylacrylonitriles followed by a deprotection/cyclization/tautomerization sequence afforded tetrasubstituted N-unprotected trans-2-pyrrolines in up to 96% yield.

Microwave synthesis of α-cyano chalcones

A novel methodology for facile production of α-cyano chalcones under microwave irradiation is described. Utilizing a Knoevenagel condensation between benzoylacetonitriles and aromatic aldehydes, substituted chalcones are generated via a 15-min, one-pot synthesis. Diversification of aromatic groups, including electron-withdrawing, electron-donating, and heterocyclic substitutions, has led to the isolation of over twenty colored, solid chalcone products. Furthermore the methodology can be extended to the synthesis of benzylidenemalononitriles as well as methyl and ethyl α-cyano cinnamates.