612833-60-0

Basic information

• Product Name: Benzene, 1-[(4-fluorophenyl)methoxy]-4-(trifluoromethyl)-
• CAS NO: 612833-60-0
• Molecular Formula: C14H10F4O
• Molecular Weight: 270.226
• Mol File: 612833-60-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, 1-[(4-fluorophenyl)methoxy]-4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-[(4-fluorophenyl)methoxy]-4-(trifluoromethyl)-(612833-60-0)
• EPA Substance Registry System: Benzene, 1-[(4-fluorophenyl)methoxy]-4-(trifluoromethyl)-(612833-60-0)

Safety Data

• Hazardous Substances Data: 612833-60-0(Hazardous Substances Data)

Upstream product

• 459-56-3 4-fluorobenzylic alcohol 
• 402-43-7 p-trifluoromethylphenyl bromide 

Relevant articles and documents

A Unified and Practical Method for Carbon–Heteroatom Cross-Coupling using Nickel/Photo Dual Catalysis

While carbon–heteroatom cross-coupling reactions have been extensively studied, many methods are specific and limited to a particular set of substrates or functional groups. Reported here is a general method that allows for C?O, C?N and C?S cross-coupling reactions under one general set of conditions. We propose that an energy transfer pathway, in which an iridium photosensitizer produces an excited nickel(II) complex, is responsible for the key reductive elimination step that couples aryl bromides, iodides, and chlorides to 1° and 2° alcohols, amines, thiols, carbamates, and sulfonamides, and is amenable to scale up via a flow apparatus.

PHENYL COMPOUNDS

Compounds of formula (I) or derivatives thereof: wherein A, B, Z, R, R, R, R, R, and R are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.