61310-29-0

Basic information

• Product Name: 2-(4-PYRIDINYL)-4-PYRIMIDINAMINE
• Synonyms: 2-(4-PYRIDINYL)-4-PYRIMIDINAMINE;2-(Pyridin-4-yl)pyriMidin-4-aMine
• CAS NO: 61310-29-0
• Molecular Formula: C₉H₈N₄
• Molecular Weight: 172.19
• Mol File: 61310-29-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 262-264°C
• Boiling Point: 279.6ºC at 760 mmHg
• Flash Point: 147.5°C
• Appearance: /
• Density: 1.259g/cm3
• Vapor Pressure: 0.00397mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: 2-(4-PYRIDINYL)-4-PYRIMIDINAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-PYRIDINYL)-4-PYRIMIDINAMINE(61310-29-0)
• EPA Substance Registry System: 2-(4-PYRIDINYL)-4-PYRIMIDINAMINE(61310-29-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 61310-29-0(Hazardous Substances Data)

Usage

General Description

2-(4-Pyridinyl)-4-pyrimidinamine is a chemical compound with the molecular formula C9H8N4. It is a derivative of pyridine and pyrimidine, and is commonly used as a building block in the synthesis of pharmaceutical compounds and organic molecules. It has been identified as a potential inhibitor of certain biological processes and has shown promise in the development of new drugs for the treatment of various diseases. The compound is also used in chemical research and is known for its diverse range of applications in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C9H8N4/c10-8-3-6-12-9(13-8)7-1-4-11-5-2-7/h1-6H,(H2,10,12,13)

Upstream product

• 7461-50-9 2-chloropyrimidin-4-amine 
• 1692-15-5 4-pyridylboronic acid 
• 6345-27-3 4-amidinopyridine hydrochloride 
• 920-37-6 2-Chloroacrylonitrile 

Downstream Products

• 61310-14-3 1-cyclohexyl-3-(2-pyridin-4-yl-pyrimidin-4-yl)-urea 
• 1459140-19-2 1-(3,4-dichlorophenyl)-3-(2-(pyridin-4-yl)pyrimidin-4-yl)urea 
• 61310-12-1 1-tert-butyl-3-(2-pyridin-4-yl-pyrimidin-4-yl)-urea 

Relevant articles and documents

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase

Human cells utilize a variety of complex DNA repair mechanisms in order to combat constant mutagenic and cytotoxic threats from both exogenous and endogenous sources. The RecQ family of DNA helicases, which includes Bloom helicase (BLM), plays an important function in DNA repair by unwinding complementary strands of duplex DNA as well as atypical DNA structures such as Holliday junctions. Mutations of the BLM gene can result in Bloom syndrome, an autosomal recessive disorder associated with cancer predisposition. BLM-deficient cells exhibit increased sensitivity to DNA damaging agents indicating that a selective BLM inhibitor could be useful in potentiating the anticancer activity of these agents. In this work, we describe the medicinal chemistry optimization of the hit molecule following a quantitative high-throughput screen of >355,000 compounds. These efforts lead to the identification of ML216 and related analogs, which possess potent BLM inhibition and exhibit selectivity over related helicases. Moreover, these compounds demonstrated cellular activity by inducing sister chromatid exchanges, a hallmark of Bloom syndrome.

N-(2-(pyridinyl)-4-pyrimidinyl)-aminomethylenemalonates and analogs

Compounds useful as anti-allergic agents are 2-Q-4-[XZC=C(R)NH]-5-R1 -6-R2 -pyrimidines (I), where Q is 4- or 3- or 2-pyridinyl or 4- or 3- or 2-pyridinyl having one or two lower-alkyl substituents or N-oxide thereof, R is hydrogen or lower-alkyl, R1 is hydrogen, lower-alkyl or cyano, R2 is hydrogen, lower-alkyl, hydroxy or halo, X and Z are the same or different and are each selected from lower-carbalkoxy, lower-alkanoyl, carbamyl and cyano, or STR1 where R3 and R4 are each lower-alkyl, or X is hydrogen, are prepared by reacting 4-amino-2-Q-5-R1 -6-R2 -pyrimidine (II where Q' is amino) with R'O-C-(R)=CXZ (III). Preparations of II are given. Also shown as intermediates and/or anti-allergic agents are 4-(AcNH)-2-Q-5-R1 -6-R2 -pyrimidines (IV) and 4-(R5 R6 N)-2-Q-5-R1 -6-R2 -pyrimidines (V) where Ac is lower-alkanoyl or lower-carbalkoxy, R5 is hydrogen, lower-alkyl or lower-hydroxyalkyl, and R6 is lower-alkyl or lower-hydroxyalkyl.