61310-31-4

Basic information

• Product Name: 2-(3-PYRIDINYL)-4-PYRIMIDINAMINE
• Synonyms: 2-(3-PYRIDINYL)-4-PYRIMIDINAMINE;2-(Pyridin-3-yl)pyriMidin-4-aMine
• CAS NO: 61310-31-4
• Molecular Formula: C₉H₈N₄
• Molecular Weight: 172.19
• Mol File: 61310-31-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 161-163°C
• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-(3-PYRIDINYL)-4-PYRIMIDINAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-PYRIDINYL)-4-PYRIMIDINAMINE(61310-31-4)
• EPA Substance Registry System: 2-(3-PYRIDINYL)-4-PYRIMIDINAMINE(61310-31-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 61310-31-4(Hazardous Substances Data)

Usage

General Description

2-(3-pyridinyl)-4-pyrimidinamine is a chemical compound with the molecular formula C9H8N4. It is an organic compound with a pyridine ring and a pyrimidine ring, which are both heterocyclic aromatic rings. 2-(3-PYRIDINYL)-4-PYRIMIDINAMINE is used in the field of medicinal chemistry as it has shown potential as a kinase inhibitor and has been studied for its potential anti-cancer properties. It is also used as a building block in the synthesis of various pharmaceutical compounds. 2-(3-pyridinyl)-4-pyrimidinamine is an important chemical for the development of new drugs and has garnered significant interest in the scientific community for its potential therapeutic applications.

Upstream product

• 7356-60-7 pyridine-3-carboxamidine hydrochloride 
• 920-37-6 2-Chloroacrylonitrile 
• 58243-08-6 (E)-3-ethoxyacrylonitrile 
• 7356-60-7 nicotinamidine; dihydrochloride 

Relevant articles and documents

Preparation of 2-(pyridinyl)-4-pyrimidinamines

The process of reacting a PY-carboxamidine with α-chloroacrylonitrile in the presence of an acid-acceptor to produce 2-PY-4-pyrimidinamines where PY is 4- or 3- or 2-pyridinyl or 4- or 3- or 2-pyridinyl having one or two lower-alkyl substituents. The products produced by the process are useful as anti-allergic agents per se and, also, are useful as intermediates in the preparation of other anti-allergic agents, namely, dialkyl N-(2-PY-4-pyrimidinyl)-aminomethylenemalonates and analogs, as well as N-(2-PY-4-pyrimidinyl)ureas.

N-[2-(pyridinyl)-4-pyrimidinyl]ureas

Compounds useful as anti-allergic agents are N-R3 -N-R4 -N'-R-N'-(2-Q-5-R1 -6-R2 -4-pyrimidinyl)ureas (I), where Q is 4- or 3- or 2-pyridinyl or 4- or 3- or 2-pyridinyl having one or two lower-alkyl substituents or N-oxide thereof, R is hydrogen or lower-alkyl, R1 is hydrogen, lower-alkyl or cyano, R2 is hydrogen or lower-alkyl, R3 is hydrogen, lower-alkyl or lower-hydroxyalkyl, R4 is hydrogen, lower-alkyl, lower-hydroxyalkyl, lower-alkenyl or lower-cycloalkyl. Said ureas are prepared by reacting 2-Q-4-RNH-5-R1 -6-R2 -pyrimidine (II) with a carbamylating agent selected from an R4 '-isocyanate of the formula R4 'N=C=O to produce N-R4 '-N'-R-N'-(2-Q-5-R1 -6-R2 -4-pyrimidinyl)urea (IA), an N-R3 '-N-R4 '-carbamyl halide of the formula R3 'R4 'NC(=O)-halide to produce N-R3 '-N-R4 'N'-R-N'-(2-Q-5-R1 -6-R2 -4-pyrimidinyl)urea (IB) or 1,1'-carbonyldiimidazole to produce N-(2-Q-5-R1 -6-R2 -4-pyrimidinyl)-N-R-imidazole-1-carboxamide and then reacting said 1-carboxamide with R3 R4 NH to produce I.