61314-87-2

Basic information

• Product Name: L-Cysteine, S-[(4-methoxyphenyl)methyl]-, methyl ester
• Synonyms: H-Cys(p-OMe-Bzl)-OMe;S-(4-methoxybenzyl)cysteine methyl ester;(R)-2-Amino-3-(4-methoxy-benzylsulfanyl)-propionic acid methyl ester;H-Cys(p-methoxybenzyl)-OMe;(R)-2-Amino-3-(4-methoxy-benzylsulfanyl)propionic acid methyl ester;H-Cys(MBzl)-OMe
• CAS NO: 61314-87-2
• Molecular Formula: C12H17NO3S
• Molecular Weight: 255.338
• Mol File: 61314-87-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: L-Cysteine, S-[(4-methoxyphenyl)methyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Cysteine, S-[(4-methoxyphenyl)methyl]-, methyl ester(61314-87-2)
• EPA Substance Registry System: L-Cysteine, S-[(4-methoxyphenyl)methyl]-, methyl ester(61314-87-2)

Safety Data

• Hazardous Substances Data: 61314-87-2(Hazardous Substances Data)

Upstream product

• 23619-36-5 Z(OMe)-Cys(MBzl)-OH 
• 2544-31-2 S-(4-methoxybenzyl)-L-cysteine 
• 77-76-9 2,2-dimethoxy-propane 
• 67-56-1 methanol 
• 76614-97-6 ammonium chloride salt of S-p-methoxybenzyl-(2R)-cysteine 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 83176-23-2 N-tert-butyloxycarbonyl-S-(4-methoxybenzyl)cysteine methyl ester 
• 75946-61-1 Z(OMe)-Asn-Tyr-Cys(MBzl)-NHNH₂ 
• 78075-38-4 Z(OMe)-Asn-Tyr-Cys(MBzl)-OMe 

Relevant articles and documents

Bio-inspired nitrile hydration by peptidic ligands based on L-cysteine, L-methionine or L-penicillamine and pyridine-2,6-dicarboxylic acid

Nitrile hydratase (NHase, EC 4.2.1.84) is a metalloenzyme which catalyses the conversion of nitriles to amides. The high efficiency and broad substrate range of NHase have led to the successful application of this enzyme as a biocatalyst in the industrial syntheses of acrylamide and nicotinamide and in the bioremediation of nitrile waste. Crystal structures of both cobalt(III)- and iron(III)-dependent NHases reveal an unusual metal binding motif made up from six sequential amino acids and comprising two amide nitrogens from the peptide backbone and three cysteine-derived sulfur ligands, each at a different oxidation state (thiolate, sulfenate and sulfinate). Based on the active site geometry revealed by these crystal structures, we have designed a series of small-molecule ligands which integrate essential features of the NHase metal binding motif into a readily accessible peptide environment. We report the synthesis of ligands based on a pyridine-2,6-dicarboxylic acid scaffold and L-cysteine, L- S-methylcysteine, L-methionine or L-penicillamine. These ligands have been combined with cobalt(III) and iron(III) and tested as catalysts for biomimetic nitrile hydration. The highest levels of activity are observed with the L-penicillamine ligand which, in combination with cobalt(III), converts acetonitrile to acetamide at 1.25 turnovers and benzonitrile to benzamide at 1.20 turnovers.

INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.