613263-26-6Relevant articles and documents
Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles
Romagnoli, Romeo,Baraldi, Pier Giovanni,Jung, M. Katherine,Iaconinoto, Maria Antonietta,Carrion, Maria Dora,Remusat, Vincent,Preti, Delia,Tabrizi, Mojgan Aghazadeh,Francesca, Fruttarolo,De Clercq, Erik,Balzarini, Jan,Hamel, Ernest
, p. 4048 - 4052 (2005)
A new series of compounds, in which the 2-amino-4-methoxyphenyl ring of phenstatin analogue 5 was replaced with 2- or 3-amino-benzoheterocycles, was synthesized and evaluated for antiproliferative activity and inhibition of colchicine binding. The lack of
Synthesis and biological evaluation of 2-(3′,4′,5′- trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents
Romagnoli, Romeo,Baraldi, Pier Giovanni,Cara, Carlota Lopez,Hamel, Ernest,Basso, Giuseppe,Bortolozzi, Roberta,Viola, Giampietro
experimental part, p. 5781 - 5791 (2011/02/22)
The biological importance of microtubules in mitosis, as well as in interphase, makes them an interesting target for the development of anticancer agents. Small molecules such as benzo[b]thiophenes are attractive as inhibitors of tubulin polymerization. T
