61342-80-1

Basic information

• Product Name: L-Tyrosine, O-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester
• Synonyms: t-butyl 3-(4-t-butyloxyphenyl)-2-aminopropionate;O-(tert-butyl) tert-butyl L tyrosinate;(S)-tert-butyl 2-amino-3-(4-tert-butoxyphenyl)propanoate;H-Tyr(tBu)-OtBu;Tyr(tBu)-OtBu;tert-butyl (S)-O4-tert-butyltyrosinate
• CAS NO: 61342-80-1
• Molecular Formula: C17H27NO3
• Molecular Weight: 293.406
• Mol File: 61342-80-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: L-Tyrosine, O-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosine, O-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester(61342-80-1)
• EPA Substance Registry System: L-Tyrosine, O-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester(61342-80-1)

Safety Data

• Hazardous Substances Data: 61342-80-1(Hazardous Substances Data)

Upstream product

• 1634-04-4 tert-butyl methyl ether 
• 60-18-4 L-tyrosine 
• 540-88-5 acetic acid tert-butyl ester 
• 71989-38-3 Fmoc-Tyr(tBu)-OH 
• 129460-19-1 N-(9-fluorenylmethoxycarbonyl)(O-tert-butyl)tyrosine tert-butyl ester 

Downstream Products

• 16870-43-2 L-tyrosine hydrochloride 
• 1246222-75-2 C₂₄H₃₈N₂O₅ 
• 1246222-76-3 C₂₅H₄₀N₂O₅ 

Relevant articles and documents

Fluorine-containing sulfonyl compound as well as intermediate, preparation method and application thereof

The invention discloses a fluorine-containing sulfonyl compound as well as an intermediate, a preparation method and application thereof. The fluorine-containing sulfonyl compound disclosed by the invention comprises positive ions and negative ions, wherein the positive ions are shown as the formula I. The fluorine-containing sulfonyl compound can react with substrates to effectively synthetize the fluorine-containing sulfonyl compound; the toxicity is low; the preparation is simple; the use is convenient; the fluorine-containing sulfonyl compound is in a solid stable state at normal temperature. In addition, the substrate applicability of the compound is extremely wide, and a phenol compound and an amine compound can be included; the fluorine-containing sulfonyl compound is a unique solidformation reagent capable of realizing the chemical conversion at present, so that important academic and application values are realized. The formula I is shown in the description.

Enantiospecific C-H Activation Using Ruthenium Nanocatalysts

The activation of C-H bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific C-H activation has been developed to date. We herein report an enantiospecific C-H activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity for the α-position of the directing heteroatom results from a four-membered dimetallacycle as the key intermediate. This work paves the way to novel molecular chemistry on nanoparticles.

αvβ3 integrin-targeting Arg-Gly-Asp (RGD) peptidomimetics containing oligoethylene glycol (OEG) spacers

RGD peptides are used in biomaterials science for surface modifications with a view to elicit selective cellular responses. Our objective is to replace peptides by small peptidomimetics acting similarly. We designed novel molecules targeting αvβ3 integrin and featuring spacer-arms (for surface grafting), which do not disturb the biological activity, from (L) N-(3-(trifluoromethyl)benzenesulfonyl) tyrosine used as scaffold. Various Arg-mimics were fixed on the phenol function, and the ortho position was used for the coupling of OEG spacers. All peptidomimetics were active in the nM range in a binding test toward human αvβ 3 integrin (IC50 = 0.1 to 1.7 nM) and selective versus platelet integrin αIIbβ3. Selected compounds revealed excellent ability to inhibit bone cells adhesion on vitronectin. Modeling and docking studies were performed for comparing the most active RGD peptidomimetic to cilengitide, i.e., cyclo-[RGDfN(Me)V]-. Lastly, the adhesion of endothelial cells on a cultivation support grafted with RGD peptidomimetics was significantly improved. 2009 American Chemical Society.