61367-36-0 Usage
Description
1-(2-chloroethyl)-3-heptan-2-ylurea, with the molecular formula C11H23ClN2O, is a chemical compound that functions as an alkylating agent. It is utilized in the field of cancer chemotherapy, specifically targeting the growth and spread of cancer cells within the body.
Uses
Used in Cancer Chemotherapy:
1-(2-chloroethyl)-3-heptan-2-ylurea is used as an anticancer agent for treating various types of cancer, such as Hodgkin's disease, lymphoma, and lung cancer. It operates by disrupting the growth and spread of cancer cells, making it a valuable tool in the fight against these diseases.
Used in Clinical Settings:
This chemical compound is typically administered intravenously in a clinical setting, where its effects can be closely monitored and managed by healthcare professionals. Due to its potential toxicity and side effects, such as nausea, vomiting, and hair loss, the use of 1-(2-chloroethyl)-3-heptan-2-ylurea requires careful consideration and ongoing assessment to ensure patient safety and treatment efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 61367-36-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,3,6 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 61367-36:
(7*6)+(6*1)+(5*3)+(4*6)+(3*7)+(2*3)+(1*6)=120
120 % 10 = 0
So 61367-36-0 is a valid CAS Registry Number.
61367-36-0Relevant articles and documents
Synthesis of analogues of N (2 chloroethyl) N' trans 4 methylcyclohexyl) N nitrosourea for evaluation as anticancer agents
Johnston,McCaleb,Clayton,Frye,Krauth,Montgomery
, p. 279 - 290 (2007/10/04)
The superior activity of N (2 chloroethyl) N' (trans 4 methylcyclohexyl) N nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans 3 methylcyclohexyl, cis 2 methyl 1,3 dithian 5 yl, cis and trans 2 methyl 1,3 dithian 5 yl tetraoxide, and 1 methylhexyl (open chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but 3 analogues effected 50% cure rates at nontoxic doses, the open chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans 4) isomers were, with one exception, as active as or, in 4 of the 8 examples, somewhat more active than the corresponding axial equatorial (cis 4) isomers. In this series, 4 of the 5 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2 chloroethyl analogues.