61390-67-8

Basic information

• Product Name: Benzene, 1,1'-(1,4-butanediyl)bis[4-(bromomethyl)-
• CAS NO: 61390-67-8
• Molecular Formula: C18H20Br2
• Molecular Weight: 396.165
• Mol File: 61390-67-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, 1,1'-(1,4-butanediyl)bis[4-(bromomethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,1'-(1,4-butanediyl)bis[4-(bromomethyl)-(61390-67-8)
• EPA Substance Registry System: Benzene, 1,1'-(1,4-butanediyl)bis[4-(bromomethyl)-(61390-67-8)

Safety Data

• Hazardous Substances Data: 61390-67-8(Hazardous Substances Data)

Upstream product

• 1083-56-3 1,4-diphenylbutane 
• 110-88-3 1,3,5-Trioxan 
• 50-00-0 formaldehyd 
• 886-65-7 trans,trans-1,4-Diphenyl-1,3-butadiene 

Downstream Products

• 7277-84-1 <2.4>Paracyclophan 
• 7568-23-2 1,4-di-p-tolylbutane 
• 89604-00-2 C₃₀H₃₂N₄O₂⁽²⁺⁾*2Br^(1-) 
• 203246-33-7 (4-{4-[4-(Dimethoxy-phosphorylmethyl)-phenyl]-butyl}-benzyl)-phosphonic acid dimethyl ester 
• 203192-01-2 1,1'-[4,4'-(butane-1,4-diyl)bis(1,4-phenylene)]bis(methylene)bis(4-(dimethylamino)pyridinium) dibromide 
• 1365672-04-3 1-(4-{4-[4-(bromomethyl)phenyl]butyl}benzyl)-4-(dimethylamino)pyridinium bromide 
• 1365671-64-2 1-[4-(4-{4-[(6-amino-9H-purin-9-yl)methyl]phenyl}butyl)benzyl]-4-(dimethylamino)pyridinium bromide 
• 1365671-79-9 1-[4-(4-{4-[(6-amino-3H-purin-3-yl)methyl]phenyl}butyl)benzyl]-4-(dimethylamino)pyridinium bromide 
• 1365671-67-5 1-[4-(4-{4-[(6-amino-9H-purin-9-yl)methyl]phenyl}butyl)benzyl]-4-pyrrolidinopyridinium bromide 
• 1365671-82-4 1-[4-(4-{4-[(6-amino-3H-purin-3-yl)methyl]phenyl}butyl)benzyl]-4-pyrrolidinopyridinium bromide 
• 1365672-08-7 1-(4-{4-[4-(bromomethyl)phenyl]butyl}benzyl)-4-pyrrolidinopyridinium bromide 

Relevant articles and documents

DIAGNOSING AND TREATING CANCER

The invention relates to compositions and methods for diagnosing as well as treating cancer diseases associated with choline kinase (ChoK). Specifically, the invention relates to a composition comprising an intrinsically fluorescent choline kinase (ChoK)

Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: A systematic investigation of the influence of linker and cationic heads over affinity and selectivity

A molecular library of quaternary ammonium salts (QASs), mainly composed of symmetrical bis-quaternary heterocyclic bromides exhibiting choline kinase (ChoK) inhibitory activity, were evaluated for their ability to inhibit acetyl- and butyrylcholinesterase (AChE and BChE, respectively). The molecular framework of QASs consisted of two positively charged heteroaromatic (pyridinium or quinolinium) or sterically hindered aliphatic (quinuclidinium) nitrogen rings kept at an appropriate distance by lipophilic rigid or semirigid linkers. Many homodimeric QASs showed AChE and BChE inhibitory potency in the nanomolar range along with a low enzymatic selectivity. Computational studies on AChE, BChE, and ChoK allowed identification of the key molecular determinants for high affinity and selectivity over either one of the three enzymes and guided the design of a hybrid bis-QAS (56) exhibiting the highest AChE affinity (IC50 = 15 nM) and selectivity over BChE and ChoK (SI = 50 and 562, respectively) and a promising pharmacological potential in myasthenia gravis and neuromuscular blockade.