61394-50-1 Usage
Description
5-CYANOOXINDOLE, also known as 2-Oxoindoline-5-carbonitrile, is an organic compound that serves as a key building block in the synthesis of various pharmaceuticals and bioactive molecules. Its unique structure, featuring a cyano group and an oxindole core, makes it a versatile intermediate for the development of novel therapeutic agents.
Uses
Used in Pharmaceutical Industry:
5-CYANOOXINDOLE is used as a reactant in the preparation of indolinone-based kinase inhibitors for the treatment of various diseases, including cancer and inflammatory disorders. Its incorporation into these inhibitors enhances their potency and selectivity, making them more effective in targeting specific kinases involved in disease progression.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 5-CYANOOXINDOLE is utilized as a starting material for the synthesis of diverse bioactive compounds with potential therapeutic applications. Its reactivity and functional group compatibility allow for the development of new chemical entities with improved pharmacological properties.
Used in Drug Discovery:
5-CYANOOXINDOLE plays a crucial role in drug discovery efforts, as it can be employed to generate novel lead compounds with potential therapeutic benefits. Its unique structural features enable the design of innovative molecules that can modulate biological targets, offering new avenues for the treatment of various diseases.
Overall, 5-CYANOOXINDOLE is a valuable chemical entity with a wide range of applications in the pharmaceutical and chemical industries, contributing to the advancement of drug development and the discovery of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 61394-50-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,3,9 and 4 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 61394-50:
(7*6)+(6*1)+(5*3)+(4*9)+(3*4)+(2*5)+(1*0)=121
121 % 10 = 1
So 61394-50-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H6N2O/c10-5-6-1-2-8-7(3-6)4-9(12)11-8/h1-3H,4H2,(H,11,12)
61394-50-1Relevant articles and documents
CONJUGATES OF AMPK INHIBITORS AND PROTAC DEGRADERS AND RELATED USES
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Paragraph 0333; 0364-0366, (2022/01/12)
The present disclosure relates to compounds of Formula (I): T-L-D, stereoisomers thereof, prodrugs thereof, and pharmaceutically acceptable salts thereof, wherein T is an AMPK inhibiting moiety; L is a linking moiety; and D is a PROTAC degrading moiety. The present disclosure also relates to uses of the compounds, e.g., to inhibit AMP-Activated protein kinase (AMPK), degrading AMPK protein, and/or treat cancer in a subject.
AMP-ACTIVATED PROTEIN KINASE INHIBITORS AND METHODS OF MAKING AND USING THE SAME
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Page/Page column 78-79, (2021/01/23)
The present disclosure relates to compounds of Formula (I): (I); stereoisomers thereof, prodrugs thereof, and pharmaceutically acceptable salts thereof. The present disclosure also relates to uses of the compounds, e.g., to inhibit AMP-Activated protein kinase (AMPK) and treat cancer in a subject.
SPIROCHROMANE DERIVATIVES
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, (2020/02/06)
The invention relates to spirochromane derivatives, or pharmaceutically acceptable salts, biologically active metabolites, pro-drugs, racemates, enantiomers, diastereomers, solvates and hydrates thereof, as well as to pharmaceutical compositions containin
