61396-68-7Relevant articles and documents
Synthesis, phase behavior and absolute configuration of β-adrenoblocker bupranolol and related compounds
Bredikhin, Alexander A.,Bredikhina, Zemfira A.,Kurenkov, Alexey V.,Zakharychev, Dmitry V.,Gubaidullin, Aidar T.
, p. 157 - 165 (2018/07/25)
β-Blocker bupranolol 1, it's hydrochloride and their precursors 1-(2-chloro-5-methylphenoxy)-2,3-epoxypropane 2 and 3-(2-chloro-5-methylphenoxy)propane-1,2-diol 3 were prepared in racemic and single-enantiomer forms. For all the studied compounds phase behavior during crystallization was established on the basis of IR, DSC and X-ray investigations. Absolute configurations were established for compounds 1 and 2. Being conglomerate, racemic oxirane 2 was resolved by direct entrainment procedure. Being anticonglomerate, in the process of recrystallization, almost enantiopure 1·HCl accumulates in the mother liquor, not in the crystalline precipitate.