614-37-9 Usage
Description
1-(4-fluorophenyl)-3-(pyrrolidin-1-yl)propan-1-one, also known as 4F-PPP, is a synthetic compound belonging to the cathinone class of chemicals. It is structurally related to pyrovalerone and is recognized as a psychoactive drug. 4F-PPP acts as a stimulant and entactogen, producing effects such as increased energy, euphoria, and enhanced sociability. However, it has a high potential for abuse and dependence, leading to its classification as unsafe and illegal in many jurisdictions due to its harmful physical and psychological effects, including cardiovascular complications and addiction.
Uses
Used in Research Applications:
1-(4-fluorophenyl)-3-(pyrrolidin-1-yl)propan-1-one is used as a research chemical for studying the effects and mechanisms of action of cathinone derivatives on the central nervous system. This application aids in understanding the potential risks and dangers associated with the abuse of such substances.
Used in Forensic Analysis:
In the forensic science industry, 1-(4-fluorophenyl)-3-(pyrrolidin-1-yl)propan-1-one is used as a reference compound for the identification and analysis of designer drugs and legal highs. This helps law enforcement and forensic laboratories in detecting and combating the distribution and use of these potentially harmful substances.
Check Digit Verification of cas no
The CAS Registry Mumber 614-37-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 4 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 614-37:
(5*6)+(4*1)+(3*4)+(2*3)+(1*7)=59
59 % 10 = 9
So 614-37-9 is a valid CAS Registry Number.
614-37-9Relevant articles and documents
Cytotoxicities of novel hydrazone compounds with pyrrolidine moiety: inhibition of mitochondrial respiration may be a possible mechanism of action for the cytotoxicity of new hydrazones
Kucukoglu, Kaan,Gul, Mustafa,Gul, Halise Inci,Cetin-Atalay, Rengul,Geny, Bernard
, p. 2116 - 2124 (2018/07/30)
N,N’-Bis[1-aryl-3-pyrrolidine-1-yl)propylidene]hydrazine dihydrochlorides (R1–R7) were synthesized by the reaction of 2 mols of 1-aryl-3-(pyrrolidine-1-yl)-1-propanone hydrochlorides with 1 mol of hydrazine hydrate and reported for the first time with their detailed spectral analysis and cytotoxicities towards human hepatoma (Huh7) and breast cancer (T47D) cell lines. Compounds R2, R6, and R7 with the IC50 values of 5.16, 6.96, and 5.96 μM, respectively, showed higher cytotoxic potency than the reference compound 5-FU with 7.0 μM against Huh7 cell line. However, all compounds did not show better cytotoxic activities than 5-FU against T47D cell line at the conditions studied. The representative compound of series, R2, inhibited the mitochondrial respiration at 90, 165, and 265 μM concentrations in a dose dependent manner in liver homogenates, suggesting that mitochondrial respiration may be one of the contributing factor to the cytotoxicity of the compounds synthesized. The compounds R2, R6, and R7 can be chosen as the leader compounds of this study for further studies.