6141-15-7Relevant articles and documents
Mild and efficient ligand-free copper-catalyzed condensation for the synthesis of quinazolines
Truong, Vouy Linh,Morrow, Michelle
scheme or table, p. 758 - 760 (2010/04/05)
Condensation of o-iodobenzaldehydes 1a_c with amidine hydrochlorides 2a_p under ligand-free copper-catalyzed Ullmann N-arylation conditions afforded the corresponding quinazolines 3a-r in good to excellent yields.
Carbon-carbon bond cleavage of α-hydroxybenzyl-heteroarenes to ketones and heteroarenes by catalytic action of cyanide ion based on retrobenzoin condensation
Miyashita, Akira,Suzuki, Yumiko,Takemura, Yuki,Iwamoto, Ken-Ichi,Higashino, Takeo
, p. 1 - 5 (2007/10/03)
Treatment of 4-(α-benzyl-α-hydroxybenzyl)quinazoline (2a) with potassium cyanide in DMF resulted in carbon-carbon bond cleavage to give benzyl phenyl ketone (3a) and quinazoline (4). Similar results were obtained with other 4-(α-hydroxybenzyl)quinazolines (2b-f and 7a). This reaction proceeds through retrobenzoin condensation. This condensation also proceeded in pyrazolopyrimidine (9a) triazolopyrimidine (10a), quinoxaline (11a), and benzimidazole (12a), and the imidazolium salt (16) was an effective catalyst.
