6146-23-2Relevant articles and documents
Ortho-Directed Palladium-Catalyzed Direct C-H Functionalization of 3-Picolinyl- A nd 3-(2-Cyanoethyl)pyrimidin-4(3 H)-ones with Aryl Halides
Baudequin, Christine,Bischoff, Laurent,Diallo, Thierno Mamoudou,Frippiat, Steven,Hoarau, Christophe,Levacher, Vincent,Mohamed-Cherif, Anissa,Muselli, Micka?l,Ruiz, Sandra Collado
, p. 1185 - 1190 (2020)
The ortho-directed palladium-catalyzed direct C-H arylation of 3-picolinylpyrimidin-4-one was achieved by using various aryl halides. The method was extended to C-H arylation of pyrimidin-4-ones containing a methoxy group and an aryl group at the C5 site. The 2-cyanoethyl substituent was also evaluated as an ortho-directing group. The method gives access to novel N-substituted 2-aryl or 2,5-diaryl pyrimidin-4-ones. A standard three-step deprotection sequence for the picolinyl group was also studied.
Manganese-Promoted Regioselective Direct C3-Phosphinoylation of 2-Pyridones
Chantarojsiri, Teera,Kittikool, Tanakorn,Phakdeeyothin, Kunita,Yotphan, Sirilata
supporting information, p. 3071 - 3078 (2021/07/22)
A highly efficient and regioselective manganese-induced radical oxidative direct C?P bond formation between 2-pyridones and secondary phosphine oxides was developed. The C3-selective phosphinoylation was conveniently achieved through a combination of substoichiometric manganese and persulfate oxidant under mild conditions. Various 3-phosphinoylated pyridone products can be obtained in moderate to high yields. Preliminary mechanistic studies suggest that the reaction is likely to involve a radical pathway induced by catalytically active Mn3+ species.
