61495-07-6

Basic information

• Product Name: N-(4-CHLORO-2-METHYLPHENYL)BENZENECARBOXAMIDE
• Synonyms: N-(4-CHLORO-2-METHYLPHENYL)BENZENECARBOXAMIDE;4'-CHLORO-2'-METHYLBENZANILIDE
• CAS NO: 61495-07-6
• Molecular Formula: C₁₄H₁₂ClNO
• Molecular Weight: 245.7
• Mol File: 61495-07-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 292°C at 760 mmHg
• Flash Point: 130.4°C
• Appearance: /
• Density: 1.25g/cm³
• Vapor Pressure: 0.00188mmHg at 25°C
• Refractive Index: 1.637
• CAS DataBase Reference: N-(4-CHLORO-2-METHYLPHENYL)BENZENECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-CHLORO-2-METHYLPHENYL)BENZENECARBOXAMIDE(61495-07-6)
• EPA Substance Registry System: N-(4-CHLORO-2-METHYLPHENYL)BENZENECARBOXAMIDE(61495-07-6)

Safety Data

• Hazardous Substances Data: 61495-07-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H12ClNO/c1-10-9-12(15)7-8-13(10)16-14(17)11-5-3-2-4-6-11/h2-9H,1H3,(H,16,17)

Upstream product

• 24251-12-5 tertiary amyl hypochlorite 
• 203209-58-9 N-benzylidene-4-chloro-2-methyl-aniline 
• 480438-47-9 (4-chloro-2-methylphenyl)magnesium bromide 
• 98-88-4 benzoyl chloride 
• 95-69-2 4-chloro-2-methylbenzeneamine 
• 584-70-3 N-benzoyl-2-methylaniline 

Downstream Products

• 944910-17-2 N-(2-bromomethyl-4-chloro-phenyl)-benzamide 
• 1383796-89-1 6-chloro-2-phenyl-4H-benzo[d][1,3]oxazine 
• 1383797-26-9 6-chloro-4-methyl-2-phenylbenzo[d]oxazole 
• 147611-23-2 N-(4-chloro-2-formylphenyl)benzamide 
• 98083-43-3 1-Acetyl-5-chlorindazol 
• 1027899-02-0 (3S,4S)-4-(5-Chloro-2-phenyl-1H-indol-3-yl)-3-hydroxy-piperidine-1-carboxylic acid benzyl ester 
• 1027537-83-2 4-(5-chloro-2-phenyl-1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 
• 170884-76-1 (5-chloro-2-phenylindol-3-yl)glyoxylyl chloride 
• 698-26-0 5-chloro-1H-indazole 

Relevant articles and documents

High yielding electrophilic amination with lower order and?higher order organocuprates: Application of acetone O-(4-Chlorophenylsulfonyl)oxime in the construction of the C?N bond at room temperature

Electrophilic amination reaction was performed with lower order and?higher order organocuprates using acetone O-(4-Chlorophenylsulfonyl)oxime (1). It was proceeded smoothly at room temperature in the presence of organocuprates to provide the corresponding primary amines in good yields with 10 and 60 min, respectively. The primary amine yields of the electrophilic amination of bromomagnesium organocyanocuprates and dibromomagnesium diorganocyanocuprates were obtained 52–72% and 58–83%, respectively. We observed that higher order organocuprates were more successful than lower order organocuprates in the synthesis of functionalized arylamines by electrophilic amination.

Revisiting 1-chloro-1,2-benziodoxol-3-one: Efficient: ortho -chlorination of aryls under aqueous conditions

The application of 1-chloro-1,2-benziodoxol-3-one as a powerful chlorinating agent as well as oxidant for aniline derivatives is explored. The amide directing group assisted radical mediated ortho-selective chlorination proceeds in the absence of a radical initiator. Various electronically differentiated anilides and sulfonamides are tolerated under aqueous conditions.

Challenges in the development of mGluR5 positive allosteric modulators: The discovery of CPPHA

This Letter describes, for the first time, the synthesis and SAR, developed through an iterative analog library approach, that led to the discovery of the positive allosteric modulator (PAM) of the metabotropic glutamate receptor mGluR5 CPPHA. Binding to