6154-04-7

Basic information

• Product Name: 5-Amino-2-methyl-2H-tetrazole
• Synonyms: 5-AMINO-2-METHYL-2H-TETRAZOLE;2-METHYL-5-AMINO-1H-TETRAZOLE;RARECHEM AQ NN 0463;TIMTEC-BB SBB001742;2H-Tetrazol-5-amine, 2-methyl-;2H-tetrazol-5-amine,2-methyl-;2H-Tetrazole, 5-amino-2-methyl-;2H-tetrazole,5-amino-2-methyl-
• CAS NO: 6154-04-7
• Molecular Formula: C₂H₅N₅
• Molecular Weight: 99.09
• EINECS: 1312995-182-4
• Mol File: 6154-04-7.mol
• Article Data: 20

Chemical Properties

• Melting Point: 104.5-105.5 °C
• Boiling Point: 282.9 °C at 760 mmHg
• Flash Point: 124.9 °C
• Appearance: /
• Density: 1.75 g/cm³
• Vapor Pressure: 0.00327mmHg at 25°C
• Refractive Index: 1.794
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.43±0.10(Predicted)
• CAS DataBase Reference: 5-Amino-2-methyl-2H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-2-methyl-2H-tetrazole(6154-04-7)
• EPA Substance Registry System: 5-Amino-2-methyl-2H-tetrazole(6154-04-7)

Safety Data

• Hazardous Substances Data: 6154-04-7(Hazardous Substances Data)

Usage

General Description

5-Amino-2-methyl-2H-tetrazole is a chemical compound with the molecular formula C2H6N6. It is a white crystalline solid that is soluble in water and has a melting point of 176-177 degrees Celsius. 5-Amino-2-methyl-2H-tetrazole is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and pigments. It can also be used as a stabilizer for rocket propellants and explosives. 5-Amino-2-methyl-2H-tetrazole is considered to be relatively stable under normal conditions but should be handled with care due to its potential hazardous properties.

InChI:InChI=1/C2H5N5/c1-7-5-2(3)4-6-7/h1H3,(H2,3,5)

Upstream product

• 4418-61-5 5-aminotetrazole 
• 74-88-4 methyl iodide 
• 15454-54-3 5-amino-1H-tetrazole monohydrate 
• 77-78-1 dimethyl sulfate 
• 616-38-6 carbonic acid dimethyl ester 
• 949089-83-2 N,N-dibenzyl-2-methyl-2H-tetrazol-5-amine 
• 949089-95-6 N,N-dibenzyl-1-methyl-1H-tetrazol-5-amine 
• 4418-61-5 5-amino-2H-tetrazole 
• 186581-53-3 diazomethane 

Downstream Products

• 74-90-8 hydrogen cyanide 
• 420-04-2 CYANAMID 
• 2053-29-4 methyleneamine 
• 939039-52-8 C₁₅H₉ClF₄N₆ 
• 669080-86-8 [3,5-bis(trifluoromethyl)phenylmethyl](2-methyl-2H-tetrazol-5-yl)amine 
• 949089-49-0 N-(2-(1-methoxycycloheptyl)-5-(trifluoromethyl)benzyl)-2-methyl-2H-tetrazol-5-amine 
• 949089-41-2 [2-(cyclohexyl-methoxy-methyl)-5-trifluoromethyl-benzyl]-(2-methyl-2H-tetrazol-5-yl)-amine 
• 911135-51-8 N-({2-[4-(3-chloropropoxy)phenyl]-1,3-oxazol-4-yl}methyl)-2-methyl-2H-tetrazol-5-amine 
• 956631-60-0 C₁₁H₇F₆N₅ 
• 93680-38-7 3-(p-bromophenyl)-1-(2'-methyltetrazol-5'-yl)triazene 

Relevant articles and documents

Synthesis and antileishmanial activity of 1,2,4,5-tetraoxanes against leishmania donovani

A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 μm. The most active tetraoxane, compound LC140, exhibited an IC50 value of 2.52 ± 0.65 μm on L. donovani intramacrophage amastigotes, with a selectivity index of 13.5. This compound reduced the liver parasite burden of L. donovani-infected mice by 37% after an intraperitoneal treatment at 10 mg/kg/day for five consecutive days, whereas miltefosine, an antileishmanial drug in use, reduced it by 66%. These results provide a relevant basis for the development of further tetraoxanes as effective, safe, and cheap drugs against leishmaniasis.

NEW ENDOPEROXIDE COMPOUNDS, PROCESS FOR OBTAINING THEM AND USES THEREOF FOR CONTROL OF PERKINSIOSIS IN BIVALVES

The present invention relates to new endoperoxide compounds and compositions, and to a process for producing them for prophylaxis and control of perkinsiosis in bivalves. Endoperoxide compounds with biological activity against Perkinsus olseni include 13

In vitro assessment of antimicrobial, antioxidant, and cytotoxic properties of saccharin–tetrazolyl and –thiadiazolyl derivatives: The simple dependence of the ph value on antimicrobial activity

The antimicrobial, antioxidant, and cytotoxic activities of a series of saccharin–tetrazolyl and –thiadiazolyl analogs were examined. The assessment of the antimicrobial properties of the referred-to molecules was completed through an evaluation of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values against Gram-positive and Gram-negative bacteria and yeasts. Scrutiny of the MIC and MBC values of the compounds at pH 4.0, 7.0, and 9.0 against four Gram-positive strains revealed high values for both the MIC and MBC at pH 4.0 (ranging from 0.98 to 125 μg/mL) and moderate values at pH 7.0 and 9.0, exposing strong antimicrobial activities in an acidic medium. An antioxidant activity analysis of the molecules was performed by using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method, which showed high activity for the TSMT (N-(1-methyl-2H-tetrazol-5-yl)-N-(1,1-dioxo-1,2-benzisothiazol-3-yl) amine, 7) derivative (90.29% compared to a butylated hydroxytoluene positive control of 61.96%). Besides, the general toxicity of the saccharin analogs was evaluated in an Artemia salina model, which displayed insignificant toxicity values. In turn, upon an assessment of cell viability, all of the compounds were found to be nontoxic in range concentrations of 0–100 μg/mL in H7PX glioma cells. The tested molecules have inspiring antimicrobial and antioxidant properties that represent potential core structures in the design of new drugs for the treatment of infectious diseases.