61570-79-4

Basic information

• Product Name: 2-Methylbut-3-yn-2-yl 2,2,2-trifluoroacetate
• Synonyms: 2-Methylbut-3-yn-2-yl 2,2,2-trifluoroacetate
• CAS NO: 61570-79-4
• Molecular Formula: C₇H₇F₃O₂
• Molecular Weight: 180.1244896
• Mol File: 61570-79-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 148.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.218±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Methylbut-3-yn-2-yl 2,2,2-trifluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylbut-3-yn-2-yl 2,2,2-trifluoroacetate(61570-79-4)
• EPA Substance Registry System: 2-Methylbut-3-yn-2-yl 2,2,2-trifluoroacetate(61570-79-4)

Safety Data

• Hazardous Substances Data: 61570-79-4(Hazardous Substances Data)

Upstream product

• 115-19-5 2-methyl-but-3-yn-2-ol 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 952302-12-4 methyl 5-chloro-2-[(1,1-dimethyl-2-propyn-1-yl)oxy]benzoate 
• 1435265-58-9 2,3-dimethoxy-1-((2-methylbut-3-yn-2-yl)oxy)benzene 
• 184896-34-2 1-methyl-2-[(2-methylbut-3-yn-2-yl)oxy]-4-nitrobenzene 
• 627872-50-8 [3-[(1,1-dimethyl-2-propynyl)oxy]-5-methoxy-2-(methoxymethoxy)phenoxy](triisopropyl)silane 
• 120281-58-5 1-bromo-4-<(1,1-dimethyl-2-propynyl)oxy>benzene 
• 30504-61-1 ((2-methylbut-3-yn-2-yl)oxy)benzene 
• 35816-87-6 4-(1,1-dimethylprop-2-ynyloxy)acetophenone 
• 33143-89-4 1-(1,1-dimethyl-2-propynyloxy)-4-methoxy benzene 
• 135522-22-4 2-(1',1'-dimethylpropargyloxy)benzaldehyde 
• 33143-92-9 4-[(1,1-Dimethyl-2-propynyl)oxy]benzonitrile 
• 2109-83-3 N-(4-((2-methylbut-3-yn-2-yl)oxy)phenyl)acetamide 
• 130219-69-1 3-methyl-3-<3-(trifluoromethyl)phenoxy>but-1-yne 
• 86824-63-7 2-methylbut-3-yn-2-yl 3-nitrophenyl ether 
• 129180-58-1 1-[(1,1-dimethyl-2-propynyl)oxy]-4-iodobenzene 

Relevant articles and documents

Synthesis of some novel pyrano[2,3-f]chromenone derivatives

A new series of pyrano[2,3-f]chromenone derivatives were synthesized starting from resorcinol. Resorcinol reacted with 3-chloropropanoic acid to give 7-hydroxychroman-4-one and reaction of the later compound with 2-methylbut-3-yn-2-ol led to the formation of 7-((2-methylbut-3-yn-2-yl)oxy)chroman-4-one. The obtained compound tolerated the cyclization reaction through Claisen rearrangement by heating in DMF to afford 8,8-dimethyl-2,3-dihydro-4H,8H-pyrano[2,3-f]chromen-4-one. Reaction of the later compound with various aromatic aldehydes gave the title compounds in good yields. All products were evaluated for their cytotoxic activity on the blood tumor cell line K562 and compared to reference drug, etoposide. Most of them exhibited low inhibitory activity against tumor cell line and among them, the compound possessing three methoxy groups on aromatic ring showed better cytotoxic effect.

Synthesis of Euchrestifoline Using Iron- and Palladium-Catalyzed C–H Bond Activations

We describe a short and efficient synthetic route to euchrestifoline. Key steps of our approach are the iron(III)-catalyzed Wacker-type oxidation of a chromene derivative with hexadecafluorophthalocyanine-iron (FePcF16) as catalyst, a palladium(0)-catalyzed Buchwald–Hartwig amination, and the final palladium(II)-catalyzed oxidative cyclization of the resulting diarylamine to the natural product.

NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a compound inhibiting Hsp90 and a pharmaceutical composition comprising the same as an active ingredient. The compounds represented by formula 1 and formula 2 of the present invention suppress the expression of Hsp90 so that they can inhibit the accumulation of HIF-1α, the Hsp90 client protein, and also efficiently inhibit the activation of VEGF. In addition, these compounds display low cytotoxicity, so that they can be effectively used as an active ingredient of an anti-cancer agent, a diabetic retinopathy treating agent, and an anti-arthritic agent.