61587-14-2

Basic information

• Product Name: 4-Ethoxyphenylformamide
• Synonyms: 4-Ethoxyphenylformamide
• CAS NO: 61587-14-2
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• Mol File: 61587-14-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 334.2 °C at 760 mmHg
• Flash Point: 155.9 °C
• Appearance: /
• Density: 1.125 g/cm³
• Vapor Pressure: 0.00013mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 4-Ethoxyphenylformamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Ethoxyphenylformamide(61587-14-2)
• EPA Substance Registry System: 4-Ethoxyphenylformamide(61587-14-2)

Safety Data

• Hazardous Substances Data: 61587-14-2(Hazardous Substances Data)

Usage

General Description

4-Ethoxyphenylformamide, also known as 4-Ethoxybenzamide, is an organic compound with the chemical formula C9H11NO2. It is a formamide derivative, meaning it contains a formyl group attached to an amine group. This chemical is commonly used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various drugs and pesticides. It possesses a pale yellow to brownish color and is commonly found as a solid at room temperature. 4-Ethoxyphenylformamide is also known for its mild, sweet, and floral odor. It is important to handle this chemical with care and follow proper safety protocols due to its potential hazards and risks.

InChI:InChI=1/C9H11NO2/c1-2-12-9-5-3-8(4-6-9)10-7-11/h3-7H,2H2,1H3,(H,10,11)

Upstream product

• 156-43-4 4-Ethoxyaniline 
• 2258-42-6 formyl acetic anhydride 
• 109-94-4 formic acid ethyl ester 
• 619-86-3 4-(ethoxy)benzoic acid 
• 64-18-6 formic acid 
• 99358-57-3 4-ethoxy benzoyl azide 
• 124-38-9 carbon dioxide 
• 32459-62-4 4-ethoxyphenyl isocyanate 
• 107-31-3 Methyl formate 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 47174-66-3 N,N'-bis-(4-ethoxy-phenyl)-formamidine 
• 6943-24-4 (4-ethoxy-phenyl)-(2,4-dinitro-phenyl)-amine 
• 156-43-4 4-Ethoxyaniline 
• 18469-17-5 N-methyl-N-nitroso-p-phenetidine 
• 61587-17-5 (4-Ethoxy-phenyl)-(4-methyl-2-nitro-phenyl)-amine 
• 61587-16-4 (4-Ethoxy-phenyl)-(4-nitro-3-trifluoromethyl-phenyl)-amine 
• 3154-18-5 N-methyl-p-phenetidine 
• 6628-28-0 6-ethoxy-2-methyl-quinoline 
• 62-44-2 4-ethoxyacetanilide 
• 5635-30-3 N-Formyl-N-methyl-p-phenetidin 
• 79377-23-4 N-[2-(1-ethyl-1H-[2]quinolyliden)-ethylidene]-p-phenetidine; hydriodide 

Relevant articles and documents

Preparation method of formamide compound

The invention belongs to CO. 2 The invention relates to the technical field of activation conversion and related chemistry, and provides a preparation method of a formamide compound, which uses carbon dioxide. The amide compound and phenylsilane are used as raw materials, and the formamide compound is synthesized under the action of the nano porous palladium catalyst. The invention mainly provides a novel simple catalytic system and utilizes CO. 2 C1 The catalytic system has the advantages of mild reaction conditions, simple experiment operation, good functional group compatibility and the like. Because carbon dioxide is abundant, cheap and easily available and renewable C1 , The invention has great application value and social economic benefits.

Method of N-formylating amines with a phosphonic anhydride

A method for N-formylating an amine that includes reacting the amine and a formamide compound in the presence of a phosphonic anhydride to form an N-formylated amine. The phosphonic anhydride is present in an amount of 5-100 mol % relative to a total number of moles of the amine, and the reacting is performed for 1-24 hours at a temperature of 45-100° C.

Chemoselective Schwartz Reagent Mediated Reduction of Isocyanates to Formamides

Addition of the in situ generated Schwartz reagent to widely available isocyanates constitutes a chemoselective, high-yielding, and versatile approach to the synthesis of variously functionalized formamides. Steric and electronic factors or the presence of sensitive functionalities (esters, nitro groups, nitriles, alkenes) do not compromise the potential of the method. Full preservation of the stereochemical information contained in the starting materials is observed. The use of formamides in the nucleophilic addition of organometallic reagents (Chida-Sato allylation, Charette-Huang addition to imidoyl triflate activated amides, Matteson homologation of boronic esters) is briefly investigated.