61610-64-8

Basic information

• Product Name: 1-(2-bromophenyl)propan-2-amine
• Synonyms: 1-(2-bromophenyl)propan-2-amine;2-BROMO-A-METHYL-BENZENEETHANAMINE;BENZENEETHANAMINE, 2-BROMO-A-METHYL-;Benzeneethanamine,2-bromo-α-methyl-;2-(ortho-bromophenyl)-1-methylethylamine
• CAS NO: 61610-64-8
• Molecular Formula: C₉H₁₂BrN
• Molecular Weight: 214.105
• Mol File: 61610-64-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-bromophenyl)propan-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromophenyl)propan-2-amine(61610-64-8)
• EPA Substance Registry System: 1-(2-bromophenyl)propan-2-amine(61610-64-8)

Safety Data

• Hazardous Substances Data: 61610-64-8(Hazardous Substances Data)

Usage

Description

1-(2-bromophenyl)propan-2-amine, also known as 2-bromomethamphetamine, is a chemical compound with the molecular formula C9H12BrN. It belongs to the class of substituted amphetamines and is structurally related to methamphetamine. 1-(2-bromophenyl)propan-2-amine is a psychoactive substance that acts as a central nervous system stimulant and is known for its potential for abuse. It is a controlled substance in many countries and is not approved for medical use. The chemical structure of 1-(2-bromophenyl)propan-2-amine includes a phenethylamine core with a bromine atom attached to the phenyl ring, which contributes to its biological effects and potential for abuse. Due to its psychoactive properties, this compound is considered a dangerous substance and is strictly regulated.

Uses

Used in Research Applications:
1-(2-bromophenyl)propan-2-amine is used as a research chemical for studying the effects of psychoactive substances on the central nervous system. Its structural similarity to methamphetamine allows scientists to investigate the mechanisms of action and potential risks associated with substance abuse.
Used in Forensic Analysis:
In the field of forensic science, 1-(2-bromophenyl)propan-2-amine is used as a reference compound for identifying and analyzing substances related to drug abuse and illegal drug trafficking. Its detection in biological samples can provide valuable information for criminal investigations.
Used in Drug Regulation and Control:
1-(2-bromophenyl)propan-2-amine is used as a benchmark for developing and implementing drug control policies and regulations. Understanding the properties and potential risks of this compound helps authorities to enforce stricter controls on the production, distribution, and use of similar psychoactive substances.

Upstream product

• 1071547-47-1 1-bromo-2-(2-chloro-propyl)-benzene 
• 21906-31-0 1-(2-bromophenyl)propane-2-one 
• 18698-97-0 ortho-bromophenylacetic acid 
• 55116-09-1 2-bromophenylacetyl chloride 
• 108-86-1 bromobenzene 
• 631-61-8 ammonium acetate 
• 42918-20-7 1-allyl-2-bromobenzene 

Downstream Products

• 95-20-5 2-methyl-1H-indole 
• 6872-06-6 2-methyl indoline 
• 23934-63-6 N-Benzhydryliden-2-amino-1-phenyl-propan 
• 337966-12-8 benzhydrylidene-[2-(2-bromo-phenyl)-1-methyl-ethyl]-amine 

Relevant articles and documents

Markovnikov Wacker-Tsuji Oxidation of Allyl(hetero)arenes and Application in a One-Pot Photo-Metal-Biocatalytic Approach to Enantioenriched Amines and Alcohols

The Wacker-Tsuji aerobic oxidation of various allyl(hetero)arenes under photocatalytic conditions to form the corresponding methyl ketones is presented. By using a palladium complex [PdCl2(MeCN)2] and the photosensitizer [Acr-Mes]ClO4 in aqueous medium and at room temperature, and by simple irradiation with blue led light, the desired carbonyl compounds were synthesized with high conversions (>80%) and excellent selectivities (>90%). The key process was the transient formation of Pd nanoparticles that can activate oxygen, thus recycling the Pd(II) species necessary in the Wacker oxidative reaction. While light irradiation was strictly mandatory, the addition of the photocatalyst improved the reaction selectivity, due to the formation of the starting allyl(hetero)arene from some of the obtained by-products, thus entering back in the Wacker-Tsuji catalytic cycle. Once optimized, the oxidation reaction was combined in a one-pot two-step sequential protocol with an enzymatic transformation. Depending on the biocatalyst employed, i. e. an amine transaminase or an alcohol dehydrogenase, the corresponding (R)- and (S)-1-arylpropan-2-amines or 1-arylpropan-2-ols, respectively, could be synthesized in most cases with high yields (>70%) and in enantiopure form. Finally, an application of this photo-metal-biocatalytic strategy has been demonstrated in order to get access in a straightforward manner to selegiline, an anti-Parkinson drug. (Figure presented.).

Method of treating nausea and vomiting with certain substituted-phenylalkylamino (and aminoacid) derivatives and other serotonin depleting agents

A method for the treatment of emesis in a mammal, which method comprises administering to said mammal an emesis inhibiting amount of a compound which depletes serotonin in the brain of mammals; among which are compounds having the formula: STR1 wherein, R is selected from hydrogen, loweralkyl, trifluoromethyl, carboxyl, or loweralkoxycarbonyl; R1 and R2 are hydrogen or loweralkyl; Z is trifluoromethyl or halogen; the optical isomers and pharmaceutically acceptable salts thereof; two of the preferred compounds of the invention are fenfluramine and norfenfluramine.