61616-82-8 Usage
Description
(3R,4S)-3,4-dihydrophenanthrene-3,4-diol is a chiral chemical compound with the molecular formula C14H14O2. It is a dihydrophenanthrene derivative, featuring a phenanthrene skeleton with hydroxyl groups at the 3 and 4 positions. (3R,4S)-3,4-dihydrophenanthrene-3,4-diol has two enantiomeric forms, (3R,4S) and (3S,4R), and is widely used in organic synthesis as a building block for pharmaceuticals and natural products. Its potential antioxidant and anti-inflammatory properties also make it a promising candidate for medicinal and therapeutic applications.
Uses
Used in Organic Synthesis:
(3R,4S)-3,4-dihydrophenanthrene-3,4-diol is used as a building block in the synthesis of various pharmaceuticals and natural products. Its unique structure and functional groups make it a valuable component in the development of new compounds with potential therapeutic effects.
Used in Medicinal Chemistry:
(3R,4S)-3,4-dihydrophenanthrene-3,4-diol is used as a starting material for the design and synthesis of novel drug candidates. Its chiral nature allows for the exploration of the biological activities of both enantiomers, potentially leading to the discovery of more effective and selective therapeutic agents.
Used in Antioxidant and Anti-inflammatory Applications:
Due to its potential antioxidant and anti-inflammatory properties, (3R,4S)-3,4-dihydrophenanthrene-3,4-diol is used in the development of agents that can combat oxidative stress and inflammation. These applications can be relevant in the treatment of various diseases and conditions where oxidative stress and inflammation play a significant role.
Used in Drug Delivery Systems:
(3R,4S)-3,4-dihydrophenanthrene-3,4-diol can be incorporated into drug delivery systems to improve the bioavailability and therapeutic efficacy of other compounds. Its structural features may allow for the development of novel carriers or encapsulation methods, enhancing the delivery of drugs to target sites and reducing side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 61616-82-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,6,1 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 61616-82:
(7*6)+(6*1)+(5*6)+(4*1)+(3*6)+(2*8)+(1*2)=118
118 % 10 = 8
So 61616-82-8 is a valid CAS Registry Number.
61616-82-8Relevant articles and documents
Biotransformation of phenanthrene and 1-methoxynaphthalene with Streptomyces lividans cells expressing a marine bacterial phenanthrene dioxygenase gene cluster.
Chun,Ohnishi,Misawa,Shindo,Hayashi,Harayama,Horinouchi
, p. 1774 - 1781 (2007/10/03)
The phdABCD gene cluster in a marine bacterium Nocardioides sp. strain KP7 codes for the multicomponent enzyme phenanthrene dioxygenase. phdA encoding an iron-sulfur protein large subunit alpha, phdB encoding its small subunit beta, phdC encoding ferredoxin, and phdD encoding ferredoxin reductase, were replaced in such a way that the termination codons of the preceding open reading frames were overlapped with the initiation codons of the following genes. This manipulated phdABCD gene cluster was positioned downstream of the thiostrepton-inducible promoter PtipA in a high-copy-number vector pIJ6021, and introduced into the gram-positive, soil-inhabiting, filamentous bacterium Streptomyces lividans. The recombinant S. lividans cells converted phenanthrene into a cis-diol form, which was determined to be cis-3,4-dihydroxy-3,4-dihydrophenanthrene by its UV spectral data as well as HPLC property, using the authentic sample for comparison. This biotransformation proceeded very efficiently; 200 microM and 2 mm of phenanthrene were almost completely converted to its cis-diol form in 6 h and 32 h, respectively. In addition, the S. lividans cells carrying the phdABCD gene cluster were found to transform 1-methoxynaphthalene to two products, which were identified to be 8-methoxy-2-naphthol in addition to 8-methoxy-1,2-dihydro-1,2-naphthalenediol by their EI-MS, 1H- and 13C-NMR spectral data.
