616195-95-0

Basic information

• Product Name: Benzaldehyde, 2,6-dichloro-4-[[[tris(1-methylethyl)silyl]oxy]methyl]-
• CAS NO: 616195-95-0
• Molecular Formula: C17H26Cl2O2Si
• Molecular Weight: 361.384
• Mol File: 616195-95-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 2,6-dichloro-4-[[[tris(1-methylethyl)silyl]oxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 2,6-dichloro-4-[[[tris(1-methylethyl)silyl]oxy]methyl]-(616195-95-0)
• EPA Substance Registry System: Benzaldehyde, 2,6-dichloro-4-[[[tris(1-methylethyl)silyl]oxy]methyl]-(616195-95-0)

Safety Data

• Hazardous Substances Data: 616195-95-0(Hazardous Substances Data)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 616195-94-9 3,5-dichloro(triisopropylsilyloxymethyl)benzene 

Downstream Products

• 616195-96-1 2,6-dichloro-4-hydroxymethylbenzaldehyde 

Relevant articles and documents

TETRACYCLIC INHIBITORS OF JANUS KINASES

The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

Simple, short and efficient procedure for the preparation of hydroxyl- and hydroxymethyl-substituted 2,6-dichlorobenzaldehydes

Hydroxyl- and hydroxymethyl-substituted 2,6-dichlorobenzaldehydes 1-4 have been obtained by lithiation of the corresponding TIPS-protected dichlorophenols or dichlorobenzylic alcohols followed by reaction with DMF and subsequent deprotection of the hydroxy group. Yields are high and formation of regioisomers is not observed.