616866-48-9

Basic information

• Product Name: Benzenesulfonamide, N-[(1R,2S)-3-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-4-methyl-
• CAS NO: 616866-48-9
• Molecular Formula: C12H19NO4S
• Molecular Weight: 273.353
• Mol File: 616866-48-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-[(1R,2S)-3-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[(1R,2S)-3-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-4-methyl-(616866-48-9)
• EPA Substance Registry System: Benzenesulfonamide, N-[(1R,2S)-3-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-4-methyl-(616866-48-9)

Safety Data

• Hazardous Substances Data: 616866-48-9(Hazardous Substances Data)

Upstream product

• 616866-46-7 (2R,3S)-N-(p-toluenesulfonyl)-3-methylaspartic acid dimethyl ester 

Downstream Products

• 616866-58-1 (R)-4-[(S)-5-methylene-1-(toluene-4-sulfonyl)piperidin-2-yl]pent-2-enoic acid ethyl ester 
• 616866-56-9 N-{1-[2-(tert-butyldimethylsilanyloxy)-1-methylethyl]-4-(hydroxymethyl)pent-4-enyl}-4-methylbenzenesulfonamide 
• 616866-52-5 2(S)-[2-(tert-butyl-dimethyl-silanyloxy)-1(S)-methyl-ethyl]-5-methylene-1-(toluene-4-sulfonyl)-piperidine 
• 616866-50-3 2(S)-[2-(tert-butyl-dimethyl-silanyloxy)-1(S)-methyl-ethyl]-N-(p-toluenesulfonyl)-aziridine 
• 616866-65-0 (S)-2-[(S)-5-methylene-1-(toluene-4-sulfonyl)piperidin-2-yl]propan-1-ol 
• 1143-54-0 deoxynupharidine 
• 6874-86-8 (–)-castoramine 
• 38681-18-4 nupharolutine 
• 616866-42-3 2(S)-[N-(p-toluenesulfonyl)-aziridin-2(S)-yl]-propan-1-ol 

Relevant articles and documents

Development of a flexible approach to Nuphar alkaloids via two enantiospecific piperidine-forming reactions

(Chemical Equation Presented). In this paper we describe the stereoselective synthesis of functionalized lactam 7 via two enantiospecific piperidine-forming techniques and its employment in a general synthetic approach to Nuphar alkaloids. Specifically, the formation of piperidine 18 by formal [3 + 3] cycloaddition and stepwise annelation processes is described; the latter technique was found to be significantly more efficient than the Pd-catalyzed TMM addition process. Finally, exploitation of the exocyclic alkene installed in the piperidine-forming reaction in the transformation of 18 to (-)-deoxynupharidine ((-)-2), (-)-castoramine ((-)-3), and (-)-nupharolutine ((-)-4) via intermediate lactam 7 is delineated.