61704-26-5

Basic information

• Product Name: Pyridine, 2-(4-chlorophenyl)-6-methyl-
• Synonyms: 2-(4-Chlor-phenyl)-6-methyl-pyridin;6-(p-Chlorphenyl)-2-picolin;6-methyl-2-(4-chlorophenyl)pyridine;2-(4-chloro-phenyl)-6-methyl-pyridine;Pyridine,2-(4-chlorophenyl)-6-methyl
• CAS NO: 61704-26-5
• Molecular Formula: C12H10ClN
• Molecular Weight: 203.671
• Mol File: 61704-26-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 62.5-63.5 °C
• Boiling Point: 142-152 °C(Press: 8 Torr)
• Density: 1.156±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Pyridine, 2-(4-chlorophenyl)-6-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-(4-chlorophenyl)-6-methyl-(61704-26-5)
• EPA Substance Registry System: Pyridine, 2-(4-chlorophenyl)-6-methyl-(61704-26-5)

Safety Data

• Hazardous Substances Data: 61704-26-5(Hazardous Substances Data)

Upstream product

• 18368-63-3 6-chloro-2-picoline 
• 1679-18-1 4-Chlorophenylboronic acid 
• 5315-25-3 2-bromo-6-methylpyridine 
• 637-87-6 1-Chloro-4-iodobenzene 
• 10412-98-3 5-oxohexanenitrile 
• 2867-59-6 2-aminobutanol 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 621685-64-1 (6-methylpyridin-2-yl)magnesium bromide 
• 106-39-8 bromochlorobenzene 
• 15724-88-6 trans-1-(4-chlorophenyl)-3-chloroprop-2-en-1-one 
• 108715-11-3 ethyl 2-methyl-6-(4-chlorophenyl)pyridine-3-carboxylate 

Downstream Products

• 101893-57-6 2-methyl-6-(p-tolyl)pyridine 

Relevant articles and documents

Formate-Mediated Cross-Electrophile Reductive Coupling of Aryl Iodides and Bromopyridines

Two catalytic systems for the formate-mediated cross-electrophile reductive coupling of aryl iodides with 6-bromopyridines are described. Using homogenous rhodium or heterogeneous palladium catalysts, the products of reductive biaryl cross-coupling could

Palladium-Catalyzed Cascade Reactions of I-Ketonitriles with Arylboronic Acids: Synthesis of Pyridines

This study presents the first example of the Pd-catalyzed cascade reactions of 5-oxohexanenitrile with arylboronic acids, affording important synthon 2-methylpyridines that can be further translated through C(sp3)-H functionalization to construct pyridine derivatives. Furthermore, this chemistry allows 5-oxo-5-Arylpentanenitrile to react with arylboronic acids to provide unsymmetrical 2,6-diarylpyridines. This protocol paves the way for the practical and atom economical syntheses of valuable pyridines with broad functional groups in moderate to excellent yields under mild conditions.

A Zwitterionic Palladium(II) Complex as a Precatalyst for Neat-Water-Mediated Cross-Coupling Reactions of Heteroaryl, Benzyl, and Aryl Acid Chlorides with Organoboron Reagents

The Suzuki–Miyaura cross-coupling (SMC) reactions of several heteroaryl chlorides, benzyl chlorides, and aryl acid chlorides with (hetero)arylboron reagents have been investigated in the presence of [Pd(HL1)(PPh3)Cl2] (I) [HL1 = 3-[(2,6-diisopropylphenyl)-1-imidazolio]-2-quinoxalinide] as catalyst and K2CO3 as base in neat water. The synthesis of the heterocycle-containing biaryls required the addition of 2 mol-% of a phosphine ligand (PPh3 or X-Phos). A combination of more than 115 substrates were screened and it was found that I is a versatile catalyst that can produce heterocycle-containing biaryls, diarylmethanes, and benzophenones in moderate-to-excellent yields.