61712-12-7

Basic information

• Product Name: 2-Butenoic acid, 2-methyl-3-(4-methylphenyl)-, ethyl ester, (E)-
• CAS NO: 61712-12-7
• Molecular Formula: C14H18O2
• Molecular Weight: 218.296
• Mol File: 61712-12-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 2-methyl-3-(4-methylphenyl)-, ethyl ester, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 2-methyl-3-(4-methylphenyl)-, ethyl ester, (E)-(61712-12-7)
• EPA Substance Registry System: 2-Butenoic acid, 2-methyl-3-(4-methylphenyl)-, ethyl ester, (E)-(61712-12-7)

Safety Data

• Hazardous Substances Data: 61712-12-7(Hazardous Substances Data)

Upstream product

• 6652-31-9 diethyl (1-carbethoxyethyl)phosphonate 
• 122-00-9 para-methylacetophenone 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 5720-05-8 4-methylphenylboronic acid 
• 27835-00-3 ethyl (4-methylbenzoyl)acetate 
• 52884-48-7 2-methyl-3-(p-methylphenyl)-3-oxopropionic acid ethyl ester 
• 1643935-43-6 C₁₄H₁₅F₃O₅S 
• 917-54-4 methyllithium 
• 1442668-91-8 Br^(1-)*C₁₄H₁₈NO₂^(1-)*Zn⁽²⁺⁾ 
• 766-97-2 4-n-methylphenylacetylene 
• 61746-89-2 3-hydroxy-2-methyl-3-p-tolyl-butyric acid ethyl ester 

Downstream Products

• 1643935-82-3 (1S,2S)-phenyl 4-hydroxy-1,2,3-trimethyl-5-oxo-2-(p-tolyl)cyclopent-3-enecarboxylate 
• 1643935-67-4 (2E,5E)-phenyl 3-(benzhydryloxy)-2,5-dimethyl-4-oxo-6-(p-tolyl)hepta-2,5-dienoate 
• 61712-17-2 (E)-2-methyl-3-(p-tolyl)but-2-enoic acid 
• 34716-99-9 2,3,4'-trimethylcinnamyl alcohol 

Relevant articles and documents

(E)- and (Z)-stereodefined enol phosphonates derived from β-ketoesters: Stereocomplementary synthesis of fully-substituted α,β-unsaturated esters

A versatile, robust, and stereocomplementary synthesis of fully-substituted (E)- and (Z)-stereodefined α,β-unsaturated esters 3 from accessible α-substituted β-ketoesters 1via (E)- and (Z)-enol phosphonates was achieved. The present method involves two ac

Tandem Blaise/retro-Blaise reaction for the nitrile-mediated regioselective intermolecular addition of unstabilized zinc ester enolates (Reformatsky Reagents) to 1-alkynes and 1,3-enynes

We report the novel use of a nitrile as a mediator to achieve the regioselective intermolecular addition of unstabilized zinc ester enolates (Reformatsky reagents) to 1-alkynes and 1,3-enynes. This reaction is made possible by a reversible addition of enolates to a nitrile (Blaise reaction), generating a zinc aza-enolate that, unlike zinc ester enolates, can add intermolecularly to 1-alkynes and 1,3-enynes. Subsequent removal of the nitrile through a retro-Blaise reaction generates the targeted addition product. This method is combined with a Diels-Alder reaction and subsequent oxidative aromatization, providing a tandem one-pot de novo construction of α-arylated alkanoates from Reformatsky reagents.

SYNTHESIS, MOLECULAR PROPERTIES AND PHARMACOLOGICAL ACTIVITY OF SOME p-SUBSTITUTED (E)- AND (Z)-α,β-DIMETHYLCINNAMIC ACIDS

A series of p-substituted (E)- and (Z)-α,β-dimethylcinnamic acids has been prepared and pharmacologically tested.The configurations of the acids prepared were determined from their NMR spectra.The UV spectra and the acid dissociation constants are reported.The collected data show that an extensive conjugation between the aryl and carboxy groups via the double bond does not exist, due to the steric hindrance of the α,β-dimethyl substitution on the cinnamic system.