61727-33-1 Usage
Description
5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid is an organic compound that serves as a synthetic intermediate in the pharmaceutical industry. It is characterized by its unique chemical structure, which includes a pyrimidine ring with a chlorine atom at the 5th position, a methylthio group at the 2nd position, and a carboxylic acid group at the 4th position. 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid is known for its potential applications in the development of various therapeutic agents.
Uses
Used in Pharmaceutical Industry:
5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid is used as a synthetic intermediate for the preparation of GSK3β inhibitors. These inhibitors are important in the development of treatments for various diseases, as they target the glycogen synthase kinase 3 beta (GSK3β) enzyme, which plays a role in several cellular processes and is implicated in the pathogenesis of certain conditions.
Additionally, 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid is used as a synthetic intermediate for the preparation of non-nucleoside reverse transcriptase inhibitors (NNRTIs). NNRTIs are a class of antiretroviral drugs used in the treatment of HIV infection. They work by inhibiting the reverse transcriptase enzyme, which is essential for the replication of the HIV virus. The development of NNRTIs is crucial in the ongoing fight against the HIV/AIDS pandemic, as they provide an alternative treatment option for patients who may not respond well to other antiretroviral medications.
Check Digit Verification of cas no
The CAS Registry Mumber 61727-33-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,7,2 and 7 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 61727-33:
(7*6)+(6*1)+(5*7)+(4*2)+(3*7)+(2*3)+(1*3)=121
121 % 10 = 1
So 61727-33-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H5ClN2O2S/c1-12-6-8-2-3(7)4(9-6)5(10)11/h2H,1H3,(H,10,11)
61727-33-1Relevant articles and documents
General and facial synthesis of 2-amino-5-halogenpyrimidine-4-carboxylic acids and their derivatives
Blyumin, Evgeniy V.,Neunhoeffer, Hans,Volovenko, Yulian V.
, p. 2231 - 2241 (2008/02/07)
A facile synthetic approach to 2-amino-5-halogen-pyrimidine-4-carboxylic acids from 5-halogen-2-methylsulfonylpyrimidine-4-carboxylic acid by nucleophilic displacement of the methylsulfonyl group with primary and secondary aliphatic amines has been develo
On the synthesis of 4- and 5-pyrimidinyl-diphenyl-(1-imidazolyl)methanes and their antifungal activity
Budesinsky,Vavrina,Langsadl,Holubek
, p. 539 - 547 (2007/10/02)
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