61765-62-6Relevant articles and documents
Formation of quaternary stereogenic centers by NHC-Cu-catalyzed asymmetric conjugate addition reactions with Grignard reagents on polyconjugated cyclic enones
Tissot, Matthieu,Poggiali, Daniele,Henon, Helene,Mueller, Daniel,Guenee, Laure,Mauduit, Marc,Alexakis, Alexandre
supporting information; experimental part, p. 8731 - 8747 (2012/09/25)
The copper-catalyzed conjugate addition of various Grignard reagents to polyconjugated enones (dienone and enynone derivatives) is reported. The catalyst system, composed of copper triflate and an NHC ligand, led to the unusual selective formation of the 1,4-addition products. This reaction allows for the creation of all-carbon chiral quaternary centers with enantiomeric excesses up to 99 %. The remaining unsaturation on the 1,4 adducts give access to valuable synthetic transformations. Copyright
Total Synthesis of (+/-)-Modhephene and Its Epimer, (+/-)-Epimodhephene
Smith, Amos B.,Jerris, Paula J
, p. 1845 - 1855 (2007/10/02)
This report presents three synthetic approaches to (+/-)-modhephene (1α) and (+/-)-epimodhephene (1β) from enones 10, 11, and 14, the overall yield of modephene being 10percent, 7percent, and 1.7percent, respectively.The approaches converge upon formation
