61765-93-3

Basic information

• Product Name: 4-TERT-BUTYL-PHENYL-HYDRAZINE
• Synonyms: 4-TERT-BUTYL-PHENYL-HYDRAZINE;1-(4-tert-Butylphenyl)hydrazine;p-tert-Butylphenylhydrazine
• CAS NO: 61765-93-3
• Molecular Formula: C₁₀H₁₆N₂
• Molecular Weight: 164.25
• Mol File: 61765-93-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 272.4±19.0 °C(Predicted)
• Appearance: /
• Density: 1.009±0.06 g/cm3(Predicted)
• PKA: 5.35±0.20(Predicted)
• CAS DataBase Reference: 4-TERT-BUTYL-PHENYL-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-TERT-BUTYL-PHENYL-HYDRAZINE(61765-93-3)
• EPA Substance Registry System: 4-TERT-BUTYL-PHENYL-HYDRAZINE(61765-93-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 61765-93-3(Hazardous Substances Data)

Usage

General Description

4-Tert-Butyl-Phenyl-Hydrazine, also known as TBPH, is a chemical compound with the molecular formula C12H18N2. It is a hydrazine derivative and is commonly used in organic synthesis and pharmaceutical research. TBPH is a combustible liquid with a sweet odor and may cause irritation to the skin, eyes, and respiratory system upon prolonged or repeated exposure. It is also a potential mutagen and carcinogen, and therefore, proper handling and safety precautions are necessary when working with this compound. TBPH is commonly used as an intermediate in the manufacture of various pharmaceuticals and dyes due to its versatile reactivity and structural properties.

Upstream product

• 769-92-6 4-tert-Butylaniline 
• 3972-56-3 4-(tert-butyl)chlorobenzene 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 7598-28-9 4-tert-butylphenyltosylate 

Downstream Products

• 1311965-26-0 3-amino-5,8-dichloro-1-(4-tert-butylphenyl)flavazole 
• 1293366-68-3 3-(4-(tert-butyl)phenyl)-1H-indole 
• 72596-31-7 diethyl (p-(tert-butyl)phenyl)phosphonate 
• 1386976-52-8 1-(4-tert-butylphenyl)-1H-1,2,4-triazole 

Relevant articles and documents

Visible-light-mediated phosphonylation reaction: formation of phosphonates from alkyl/arylhydrazines and trialkylphosphites using zinc phthalocyanine

In this work, we developed a ligand- and base-free visible-light-mediated protocol for the photoredox syntheses of arylphosphonates and, for the first time, alkyl phosphonates. Zinc phthalocyanine-photocatalyzed Csp2-P and Csp3-P bond formations were efficiently achieved by reacting aryl/alkylhydrazines with trialkylphosphites in the presence of air serving as an abundant oxidant. The reaction conditions tolerated a wide variety of functional groups.

One-Pot Synthesis of Indoles and Pyrazoles via Pd-Catalyzed Couplings/Cyclizations Enabled by Aqueous Micellar Catalysis

An effective one-pot synthesis of either indoles or pyrazoles can be achieved via Pd-catalyzed aminations followed by subsequent cyclizations facilitated by aqueous micellar catalysis. This new technology includes efficient couplings with low loadings of palladium, a more stable source of the required hydrazine moiety, greater atom economy for the initial coupling, and reduced reaction temperatures, all leading to environmentally responsible processes.

Thiazolylbenzofuran derivatives and pharmaceutical compositions containing them

This invention relates to novel thiazolylbenzofuran derivatives of formula (I) wherein R1 is lower alkyl, L is single bond or lower alkylene optionally substituted with aryl, oxo or hydroxy, and Q is a heterocyclic group optionally substituted with one or more suitable substituent(s); or lower alkoxy substituted with aryl which is substituted with one or more suitable substituent(s) and at least one of which is lower alkoxy optionally substituted with cyano, protected carboxy, carboxy, lower alkylene, a heterocyclic group optionally substituted with oxo, or amidino optionally substituted with hydroxy or lower alkoxy, or its salt, which possess activities as leukotriene and SRS-A antagonists or inhibitors.