61820-93-7Relevant articles and documents
Delivering 2-Aryl Benzoxazoles through Metal-Free and Redox-Neutral De-CF3Process
Qiao, Xinxin,Zhao, Yong-De,Rao, Mingru,Bu, Zhan-Wei,Zhang, Guangwu,Xiong, Heng-Ying
, p. 13548 - 13558 (2021/10/01)
An unexpected cleavage of the Csp3-CF3 bond of CF3-hydrobenzoxazoles has been disclosed, affording a range of 2-aryl benzoxazoles under metal-free and redox-neutral conditions. This transformation has demonstrated broad substrate scope and good compatibility of functional groups. 2-Aryl benzothiazole and 2-aryl benzoimidazole could be smoothly assembled in the same manner. On the basis of preliminary mechanistic studies, base initiated and aromatization driven β-carbon elimination was considered to be the key step for the formation of 2. This reaction offers an alternative, facile, and sustainable route to access important 2-aryl benzoxazole motifs.
Ruthenium-catalyzed synthesis of benzoxazoles using acceptorless dehydrogenative coupling reaction of primary alcohols with 2-aminophenol under heterogeneous conditions
Khalafi-Nezhad, Ali,Panahi, Farhad
, p. 1686 - 1692 (2014/06/24)
An efficient ruthenium-catalyzed acceptorless dehydrogenative coupling reaction of primary alcohols with 2-aminophenol for one-pot synthesis of benzoxazoles is introduced. The phosphine-functionalized magnetic nanoparticles (PFMNPs; Fe3O4@SiO2@PPh2) as a magnetic recyclable phosphorus ligand in the presence of Ru2Cl 4(CO)6 was found to be an efficient heterogeneous catalytic system for promotion of the designed protocol. The reaction was carried out efficiently with a variety of substrates to give the corresponding products in moderate to good yields.
SYNTHETIC STUDIES USING AROMATIC AMINO COMPOUNDS AND ACTIVATED NITRILES
Shafei, Ahmed K. El.,El-Sayed, Ahmed M.,Soliman, Ahmed M.
, p. 385 - 390 (2007/10/02)
Reaction of malononitrile, arylidenemalononitrile, chloroacetonitrile or ethyl cyanoacetate with o-aminobenzenethiol, o-aminophenol, 2-aminobenzothiazole, anthranilamide, o-phenylenediamine, p-nitro-o-phenylenediamine, 2-naphthylamine, 2-amino-3-hydroxypyridine or 2,3-diaminopyridine afforded a new series of nitrogen-containing mono- or poly-heterocyclic derivatives via initial addition to either the cyano or the styryl function followed by cyclization.The structure of the obtained products was elucidated by microanalyses, IR and NMR data.