61827-19-8

Basic information

• Product Name: (2E)-N-{2-hydroxy-1-[(methylsulfanyl)methyl]ethyl}-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-enamide
• CAS NO: 61827-19-8
• Molecular Formula: C₁₂H₁₇N₃O₄S
• Molecular Weight: 299.3461
• Mol File: 61827-19-8.mol
• Article Data: 0

Chemical Properties

• Density: 1.357g/cm³
• Refractive Index: 1.616
• CAS DataBase Reference: (2E)-N-{2-hydroxy-1-[(methylsulfanyl)methyl]ethyl}-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-N-{2-hydroxy-1-[(methylsulfanyl)methyl]ethyl}-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-enamide(61827-19-8)
• EPA Substance Registry System: (2E)-N-{2-hydroxy-1-[(methylsulfanyl)methyl]ethyl}-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-enamide(61827-19-8)

Safety Data

• Hazardous Substances Data: 61827-19-8(Hazardous Substances Data)

Usage

Description

(2E)-N-2-hydroxy-1-[(methylsulfanyl)methyl]ethyl-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-enamide, also known as TDP1 inhibitor, is a chemical compound with potential medicinal applications. It is an acrylamide derivative that contains a hydroxyethyl group, a methylsulfanyl group, and a tetrahydropyrimidin-5-yl ring. (2E)-N-2-hydroxy-1-[(methylsulfanyl)methyl]ethyl-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-enamide is a potent and selective inhibitor of TDP1 (tyrosyl-DNA phosphodiesterase 1), an enzyme that plays a role in DNA repair processes.

Uses

Used in Cancer Therapy:
(2E)-N-2-hydroxy-1-[(methylsulfanyl)methyl]ethyl-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-enamide is used as a therapeutic agent for cancer treatment. It targets the TDP1 enzyme, which is involved in the repair of DNA damage, thereby potentially enhancing the effectiveness of DNA-damaging anticancer therapies. By inhibiting TDP1, this compound may increase the susceptibility of cancer cells to treatments such as chemotherapy and radiation, leading to improved patient outcomes.
Used in Pharmaceutical Development:
In the pharmaceutical industry, (2E)-N-2-hydroxy-1-[(methylsulfanyl)methyl]ethyl-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-enamide is used as a lead compound for the development of new drugs. Its ability to selectively inhibit the TDP1 enzyme makes it a promising candidate for further research and development into treatments for various diseases related to DNA damage and repair.
Further research is necessary to fully understand the potential benefits and risks associated with the use of (2E)-N-2-hydroxy-1-[(methylsulfanyl)methyl]ethyl-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-enamide in these applications.