618905-84-3

Basic information

• Product Name: 1H-Pyrrole-1-aceticacid,alpha-methyl-,methylester,(alphaR)-(9CI)
• Synonyms: 1H-Pyrrole-1-aceticacid,alpha-methyl-,methylester,(alphaR)-(9CI)
• CAS NO: 618905-84-3
• Molecular Formula: C₈H₁₁NO₂
• Molecular Weight: 153.18
• Product Categories: AMINETERTIARY;GLYCINESCAFFOLD
• Mol File: 618905-84-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrole-1-aceticacid,alpha-methyl-,methylester,(alphaR)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-1-aceticacid,alpha-methyl-,methylester,(alphaR)-(9CI)(618905-84-3)
• EPA Substance Registry System: 1H-Pyrrole-1-aceticacid,alpha-methyl-,methylester,(alphaR)-(9CI)(618905-84-3)

Safety Data

• Hazardous Substances Data: 618905-84-3(Hazardous Substances Data)

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 7625-53-8 D-alanine methyl ester 
• 1476-11-5 Z-1,4-dichlorobutene 
• 14316-06-4 D-alanine methyl ester hydrochloride 

Downstream Products

• 618905-90-1 (3R)-3-(pyrrol-1-yl)but-1-ene 
• 618905-87-6 (2R)-2-(pyrrol-1-yl)propanal 

Relevant articles and documents

New and clean synthesis of N-substituted pyrroles under microwave irradiation

N-Substituted homochiral pyrrole derivatives were synthesized by the ring-closure reaction of cis-1,4-dichloro-2-butene with various amine compounds on a silica surface under microwave irradiation.

A new class of optically active pyrrole derivatives: (3R)-3-(pyrrol-1-yl)alk-1-enes from D-α-aminoacids

(3R)-3-(Pyrrol-1-yl)but-1-ene 4a, (3R)-4-methyl-3-(pyrrol-1-yl)pent-1-ene 4b, (3R)-3-(pyrrol-1-yl)hex-1-ene 4c in high enantiomeric excess (>92%) were prepared starting from D-α-amino acids. The crucial steps in the synthesis, reduction (DIBAH) of the corresponding pyrrolylesters to the corresponding pyrrolylaldehydes followed by Wittig olefination proceeded without compromising the stereochemical integrity.