619-12-5 Usage
Description
4-FORMYL-3-HYDROXYBENZOIC ACID is an organic compound with the molecular formula C8H6O4. It is a derivative of benzoic acid, featuring a formyl group (aldehyde) at the 4-position and a hydroxyl group at the 3-position. 4-FORMYL-3-HYDROXYBENZOIC ACID is known for its potential applications in various fields due to its chemical properties and reactivity.
Uses
Used in Chemical Synthesis:
4-FORMYL-3-HYDROXYBENZOIC ACID is used as a reactant for the preparation of various compounds, such as:
1. A pH-sensitive fluorescent probe, 4,4′-(hydrazine-1,2-diylidene bis(methanylylidene)) bis(3-hydroxybenzoic acid) (HDBB), which can be synthesized through a one-step condensation reaction with hydrazine. This probe is valuable for detecting changes in pH levels, which can be crucial in various research and industrial applications.
2. 2-Oxo-2H-1-benzopyran-3,7-dicarboxylic acid, which can be obtained by a condensation reaction with diethyl malonate. 4-FORMYL-3-HYDROXYBENZOIC ACID has potential applications in the synthesis of various organic compounds and materials.
3. Schiff base ligands, which are essential for the preparation of stable and functional Schiff base metal complexes. These complexes find applications in catalysis, coordination chemistry, and material science due to their unique properties and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 619-12-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 9 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 619-12:
(5*6)+(4*1)+(3*9)+(2*1)+(1*2)=65
65 % 10 = 5
So 619-12-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H6O4/c9-4-6-2-1-5(8(11)12)3-7(6)10/h1-4,10H,(H,11,12)
619-12-5Relevant articles and documents
Preparation method of benzofuran derivative
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Paragraph 0064-0068, (2020/02/06)
The invention discloses a preparation method for synthesizing a benzofuran derivative. The specific implementation method is as shown in the specification. The method has novel synthetic route, simpleand convenient operation, high yield, and good safety, and is suitable for industrial production. A novel synthetic method of an intermediate VI is also designed, a Wittig reaction is carried out, and then ring-closing is carried out to obtain a benzofuran ring.
The synthesis and evaluation of benzofuranones as β-lactamase substrates
Adediran,Cabaret,Drouillat,Pratt,Wakselman
, p. 1175 - 1183 (2007/10/03)
6- and 7-Carboxy-3-phenylacetamido-3H-1-benzofuran-2-one have been synthesized as potential β-lactamase substrates and/or inhibitors. These compounds were prepared by lactonization of the corresponding, appropriately substituted phenylglycines. The latter compounds were prepared by either the Strecker or the Buecherer-Berg method. The benzofuran-2-ones were less stable in aqueous solution than the analogous acyclic phenaceturate esters but comparably stable to analogous benzopyran-2-ones. They differed from the latter compounds however in that the C-3 hydrogen of the furan-2-ones, adjacent to the lactone carbonyl group, was distinctly acidic; 7-carboxy-3-phenylacetamido-3H-1-benzofuran-2-one exists largely as an enolate at pH 7.5. The furan-2-ones were β-lactamase substrates with reactivity very similar to the analogous acyclic phenaceturates. They were not, however, DD-peptidase inhibitors and are thus unlikely to have antibiotic activity. The structural basis for these observations is discussed.