619-16-9 Usage
Description
2-CHLORO-1,4-DINITROBENZENE is an organic compound belonging to the family of nitrobenzenes. It is characterized by its light yellow crystalline appearance and is soluble in ethanol and ether, while being insoluble in water. 2-CHLORO-1,4-DINITROBENZENE is known for its reactivity and is used as a reagent in various chemical syntheses.
Uses
Used in Pharmaceutical Industry:
2-CHLORO-1,4-DINITROBENZENE is used as a reagent for the synthesis of novel thiazole derivatives, which have potential applications as coxsackie inhibitors. These inhibitors can be employed in the development of new drugs to treat viral infections, particularly those caused by coxsackieviruses.
Used in Chemical Synthesis:
2-CHLORO-1,4-DINITROBENZENE is also used in the synthesis of other isomers, such as 4-chloro-1,2-dinitrobenzene. These isomers can have various applications in different industries, including the production of dyes, pesticides, and other chemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 619-16-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 9 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 619-16:
(5*6)+(4*1)+(3*9)+(2*1)+(1*6)=69
69 % 10 = 9
So 619-16-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H3ClN2O4/c7-5-3-4(8(10)11)1-2-6(5)9(12)13/h1-3H
619-16-9Relevant articles and documents
Aromatic radical anions as possible intermediates in the nucleophilic aromatic substitution (SNAr): An EPR study
Grossi, Loris,Strazzari, Samantha
, p. 2141 - 2146 (2007/10/03)
The reactions among halonitrobenzenes or polynitrobenzenes and alkoxides, thiolates or tertiary amines have provided the evidence that in a SNAr reaction type a single electron transfer from the nucleophile to the aromatic substrate, to generate two radical species within the solvent cage, can take place to some extent. The detection of radical intermediates by EPR spectroscopy, in several SNAr reactions, is reported.
Reactions of Nitrophenols with Phosphorus Oxychloride in Dimethylformamide
Akhtar, Nahid,Munawar, M. A.,Siddiq, M.
, p. 328 (2007/10/02)
A rapid and simple method for the replacement of hydroxyl group of nitrophenols and related compounds by chlorine using phosphorus oxychloride in dimethylformamide at ambient temperature is described.