61916-60-7

Basic information

• Product Name: 3-[(4-METHOXYPHENYL)AMINO]-3-OXOPROPANOIC ACID
• Synonyms: 3-[(4-METHOXYPHENYL)AMINO]-3-OXOPROPANOIC ACID;3-[(4-methoxyphenyl)amino]-3-oxopropanoic acid(SALTDATA: FREE)
• CAS NO: 61916-60-7
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.2
• Mol File: 61916-60-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 157 °C
• Boiling Point: 484.777°C at 760 mmHg
• Flash Point: 246.984°C
• Appearance: /
• Density: 1.327g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.593
• PKA: -0.29±0.32(Predicted)
• CAS DataBase Reference: 3-[(4-METHOXYPHENYL)AMINO]-3-OXOPROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(4-METHOXYPHENYL)AMINO]-3-OXOPROPANOIC ACID(61916-60-7)
• EPA Substance Registry System: 3-[(4-METHOXYPHENYL)AMINO]-3-OXOPROPANOIC ACID(61916-60-7)

Safety Data

• Hazardous Substances Data: 61916-60-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11NO4/c1-15-8-4-2-7(3-5-8)11-9(12)6-10(13)14/h2-5H,6H2,1H3,(H,11,12)(H,13,14)

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 104-94-9 4-methoxy-aniline 
• 5382-15-0 ethyl 3-((4-methoxyphenyl)amino)-3-oxopropanoate 

Downstream Products

• 14300-45-9 4-hydroxy-6-methoxy-1H-quinolin-2-one 
• 1441058-46-3 ethyl 2-(3-(4-methoxyphenylamino)-3-oxopropanamido)-2-methyl-4-oxo-4-p-tolylbutanoate 
• 1441058-48-5 5-(4-methoxyphenylcarbamoyl)-2-methyl-6-oxo-4-p-tolyl-1,2,3,6-tetrahydropyridine-2-carboxylic acid 
• 1441057-94-8 C₁₀H₁₀ClNO₃ 
• 1441049-36-0 N-(4-methoxyphenyl)-2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoro-methyl)-1,2,5,6-tetrahydropyridine-3-carboxamide 
• 1441066-95-0 N⁵-(4-methoxyphenyl)-2-methyl-6-oxo-4-p-tolyl-N²-(4,4,4-trifluorobutyl)-1,2,3,6-tetrahydropyridine-2,5-dicarboxamide 
• 1441057-92-6 N¹-(4-methoxyphenyl)-N³-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluoro-butoxy)phenyl)-butan-2-yl)malonamide 
• 684275-31-8 3-(2,4,6-trimethoxyphenyl)-N-(4-methoxyphenyl)prop-(2E)-enamide 
• 340258-61-9 3-(4-methoxyphenyl)-N-(4-methoxyphenyl)prop-(2E)-enamide 

Relevant articles and documents

Mild, efficient, and solvent-free synthesis of 4-hydroxy-2-quinolinones

Malonic acid monoanilides were obtained in excellent yield from the reaction of anilines with Meldrum's acid under solvent-free conditions. The malonic acid monoanilide intermediates were then treated with methanesulfonic acid anhydride (MSAA) to produce 4-hydroxy-2-quinolinones in excellent yield. It should be noted that both reactions had to be run under mild conditions to avoid the decarboxylation of the malonic acid monoanilide intermediate.

SUBSTITUTED PYRIDINONES AS MGAT2 INHIBITORS

The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.

ARYL DIHYDROPYRIDINONE AND PIPERIDINONE MGAT2 INHIBITORS

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.