61919-52-6 Usage
Description
1β-Hydroxy-6α-Methyl-1,4-androstadiene-3,17-dione is an organic compound that is classified as an impurity of Methylprednisolone (M325934). It is characterized by its off-white solid appearance and is derived from the chemical structure of androstadienedione, with specific modifications at the 1β and 6α positions.
Uses
Used in Pharmaceutical Industry:
1β-Hydroxy-6α-Methyl-1,4-androstadiene-3,17-dione is used as an impurity in the production of Methylprednisolone (M325934) for the pharmaceutical industry. Its presence, although as an impurity, is significant in the synthesis and formulation of Methylprednisolone, which is a corticosteroid medication used to treat various inflammatory conditions and autoimmune diseases.
As an impurity, it is essential to monitor and control the levels of 1β-Hydroxy-6α-Methyl-1,4-androstadiene-3,17-dione in the final product to ensure the safety, efficacy, and quality of Methylprednisolone. The pharmaceutical industry relies on stringent quality control measures to minimize the presence of impurities and maintain the therapeutic benefits of the drug.
Check Digit Verification of cas no
The CAS Registry Mumber 61919-52-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,9,1 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 61919-52:
(7*6)+(6*1)+(5*9)+(4*1)+(3*9)+(2*5)+(1*2)=136
136 % 10 = 6
So 61919-52-6 is a valid CAS Registry Number.
61919-52-6Relevant articles and documents
Caspi et al.
, p. 271,282 (1961)
Radiolytic degradation scheme for 60Co-irradiated corticosteroids
Kane,Tsuji
, p. 30 - 35 (2007/10/02)
The cobalt 60 radiolytic degradation products have been identified in the following corticosteroids: cortisone, cortisone acetate, hydrocortisone, hydrocortisone acetate, hydrocortisone sodium succinate, isoflupredone acetate, methylprednisolone, methylprednisolone acetate, prednisolone, prednisolone acetate, and prednisone. Two major types of degradation processes have been identified: loss of the corticoid side chain the D-ring to produce the C-17 ketone and conversion of the C-11 alcohol, if present, to the C-11 ketone. Minor degradation products derived from other changes affecting the side chain are also identified in several corticosteroids. These compounds are frequently associated in corticosteroids as process impurities or degradation compounds. No new radiolytic compounds unique to 60Co-irradiation have been found. The majority of corticosteroids have been shown to be stable to 60Co-irradiation. The rates of radiolytic degradation ranged from 0.2 to 1.4%/Mrad.
