619330-91-5

Basic information

• Product Name: D-Norvaline, Methyl ester (hydrochloride)(1:1)
• Synonyms: D-Norvaline, Methyl ester (hydrochloride)(1:1);(R)-Methyl 2-aminopentanoate hydrochloride
• CAS NO: 619330-91-5
• Molecular Formula: C6H14ClNO2
• Molecular Weight: 167.63386
• Mol File: 619330-91-5.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: D-Norvaline, Methyl ester (hydrochloride)(1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: D-Norvaline, Methyl ester (hydrochloride)(1:1)(619330-91-5)
• EPA Substance Registry System: D-Norvaline, Methyl ester (hydrochloride)(1:1)(619330-91-5)

Safety Data

• Hazardous Substances Data: 619330-91-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 6600-40-4 L-Norvaline 
• 498-18-0 norvaline 
• 501033-83-6 (2S,3R)-3-(tert-butoxycarbonylamino)hexane-1,2-diol 
• 2013-12-9 D-norvaline 
• 848613-42-3 2-aminopentanoic acid (hydrochloride) 
• 760-78-1 2-aminopentanoic acid 
• 27493-23-8 L-norvaline hydrochloride 
• 75-36-5 acetyl chloride 
• 220515-19-5 tert-butyl-(2S,3S)-1,2-dihydroxyhexan-3-ylcarbamate 

Relevant articles and documents

PARP1 INHIBITORS

The present invention relates to azaquinolone compounds of Formula (I), and their use in medicine. Formula (I)

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate

Carboxamide pyrazinyloxy benzoxaboroles were investigated with the goal to identify a molecule with satisfactory antimalarial activity, physicochemical properties, pharmacokinetic profile, in vivo efficacy, and safety profile. This optimization effort discovered 46, which met our target candidate profile. Compound 46 had excellent activity against cultured Plasmodium falciparum, and in vivo against P. falciparum and P. berghei in infected mice. It exhibited good PK properties in mice, rats, and dogs. It was highly active against the other 11 P. falciparum strains, which are mostly resistant to chloroquine and pyrimethamine. The rapid parasite in vitro reduction and in vivo parasite clearance profile of 46 were similar to those of artemisinin and chloroquine, two rapid-acting antimalarials. It was nongenotoxic in an Ames assay, an in vitro micronucleus assay, and an in vivo rat micronucleus assay when dosed orally up to 2000 mg/kg. The combined properties of this novel benzoxaborole support its progression to preclinical development.

Synthesis, crystal structure and biological activity screening of novel N-(α-bromoacyl)-α-amino esters containing valyl moiety

Three novel N-(α-bromoacyl)-α-amino esters: methyl 2-(2-bromo-3-methylbutanamido)pentanoate (1), methyl 2-(2-bromo-3-methylbutanamido)-2-phenylacetate (2) and methyl 2-(2-bromo-3-methylbutanamido)-3-phenylpropanoate (3) were synthesized. Single crystal X-