61959-31-7

Basic information

• Product Name: 2-(2,4-dimethoxybenzoyl)benzoic acid
• CAS NO: 61959-31-7
• Molecular Formula: C₁₆H₁₄O₅
• Molecular Weight: 286.2794
• Mol File: 61959-31-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 523.5°C at 760 mmHg
• Flash Point: 197.5°C
• Density: 1.255g/cm³
• Vapor Pressure: 8.72E-12mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 2-(2,4-dimethoxybenzoyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-dimethoxybenzoyl)benzoic acid(61959-31-7)
• EPA Substance Registry System: 2-(2,4-dimethoxybenzoyl)benzoic acid(61959-31-7)

Safety Data

• Hazardous Substances Data: 61959-31-7(Hazardous Substances Data)

Usage

Specific content

The chemical name of the compound

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The widely used name for the compound

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A chemical group to which the compound belongs

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The primary application of the compound, which involves enhancing the effects of light therapy

Specific content

The type of radiation used in conjunction with methoxsalen for treatment

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The skin conditions that can be treated with methoxsalen and UVA combination therapy

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How methoxsalen interacts with skin cells to initiate its effects

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The specific mechanism by which methoxsalen inhibits cell division and proliferation

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The result of methoxsalen's interaction with skin cells when exposed to UVA light

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Other therapeutic effects of methoxsalen that contribute to its efficacy in treating skin conditions

Category

Psoralen derivative

Use

Photosensitizing agent

Combination therapy

Ultraviolet A radiation (UVA)

Indications

Psoriasis, vitiligo, and cutaneous T-cell lymphoma

Mechanism of action

Binding to skin cell DNA

Effect

Crosslinking and damage to DNA upon UVA exposure

Outcome

Inhibition of cell division and proliferation

Additional properties

Anti-inflammatory and immunosuppressive

Upstream product

• 23949-32-8 <2-Benzoyloxymethyl-phenyl>-<2,4-dimethoxy-phenyl>-methanol 
• 23949-33-9 2-Benzoyloxymethyl-2',4'-dimethoxy-benzophenon 
• 23949-37-3 2-Chlormethyl-2',4'-dimethoxy-benzophenon 
• 24048-90-6 2-Chlormethyl-2'-hydroxy-4'-methoxy-benzophenon 
• 85-44-9 phthalic anhydride 
• 151-10-0 1,3-Dimethoxybenzene 
• 23949-38-4 2-Cyanmethyl-2',4'-dimethoxy-benzophenon 
• 855470-11-0 2-(2,4-dimethoxy-benzoyl)-benzoic acid methyl ester 

Downstream Products

• 153260-41-4 3-(2,4-Dimethoxyphenyl)-isoindolin-1-on 
• 4756-45-0 NSC 79888 
• 23949-29-3 3-(2,4-dimethoxy-phenyl)-phthalide 
• 23949-30-6 (2-Hydroxymethylphenyl)-(2,4-dimethoxyphenyl)-carbinol 
• 51671-64-8 3,3-bis-(2,4-dimethoxy-phenyl)-3H-isobenzofuran-1-one 

Relevant articles and documents

Intrinsically thermochromic fluorans

A Suzuki coupling strategy has been employed to access a series of novel fluorans substituted with a phenolic moiety. These fluorans display good thermochromism in methyl stearate and obviate the need for traditional complex formulations containing acidic colour developers.

Synthesis and Structure - Activity Relationships of Sweet 2-Benzoylbenzoic Acid Derivatives

Twenty-four analogues of the sweet compound 2-(4-methoxybenzoyl)benzoic acid 1 were synthesized and tasted. The structure-sweet taste relationships were studied by means of principal component analysis and by comparison with the existing sweet receptor models. Three possible glucophores were identified, which could correspond to the sites B, E1, and E2 of the Tinti - Nofre model. Some similarities between this class of compounds and isovanillic sweeteners were found.