62-51-1 Usage
Description
METHACHOLINE CHLORIDE, also known as acetyl-β-methylcholine, is an analog of acetylcholine. It is a cholinergic agonist that acts as a parasympathomimetic drug, mimicking the action of the neurotransmitter acetylcholine. It possesses the ability to stimulate the muscarinic acetylcholine receptors, which play a crucial role in various physiological processes.
Used in Pharmaceutical Industry:
METHACHOLINE CHLORIDE is used as a receptor agonist for studying processes such as airway hyperresponsiveness associated with asthma. It helps in understanding the underlying mechanisms of respiratory conditions and aids in the development of therapeutic strategies for asthma management.
Used in Cardiovascular Applications:
METHACHOLINE CHLORIDE is used as an antihypertensive agent to lower blood pressure. It works by stimulating the muscarinic receptors in the heart and blood vessels, leading to a reduction in heart rate and blood vessel dilation, which in turn lowers the blood pressure.
Used in Cardiology:
METHACHOLINE CHLORIDE is used as an antianginal agent to prevent and treat angina pectoris, a condition characterized by chest pain due to insufficient blood flow to the heart. By stimulating the muscarinic receptors, it helps to increase blood flow to the heart and reduce the workload on the heart muscle, thereby alleviating angina symptoms.
Biochem/physiol Actions
Metabolically stable analog of acetylcholine; muscarinic agonist. Its ability to constrict airway smooth muscle is used to assess bronchial reactivity in the laboratory and clinically.
Clinical Use
Methacholine, acetyl β-methylcholine, is marketed as the racemic mixture. It is a selective
muscarinic agonist with very little activity at nicotinic receptors. Although methacholine chloride is marketed as the racemic mixture, the
S-(+)-enantiomer is 240-fold more potent than the R-(–)-isomer at muscarinic receptors. In addition, AChE hydrolyzes S-(+)–methacholine at approximately 54% the rate of acetylcholine, whereas the R-(–)–enantiomer is a weak inhibitor. Methacholine chloride is used via inhalation for the diagnosis of asthma. The resulting bronchospasm may be relieved with bronchodilators. Methacholine chloride is available as a powder that is reconstituted for inhalation.
Purification Methods
It forms white hygroscopic needles from Et2O and is soluble in H2O, EtOH and CHCl3. It decomposes readily in alkaline solutions and slowly in H2O. It should be handled and stored in a dry atmosphere. The bromide is less hygroscopic, and the picrate has m 129.5-131o (from EtOH). [racemate: Annis & Ely Biochem J 53 34 1953, IR of iodide: Hansen Acta Chem Scand 13 155 1959, Beilstein 4 IV 1670.]
Check Digit Verification of cas no
The CAS Registry Mumber 62-51-1 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 2 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 62-51:
(4*6)+(3*2)+(2*5)+(1*1)=41
41 % 10 = 1
So 62-51-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H18NO2.ClH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1
